Fluoxetine counteracts the cognitive and cellular effects of 5-Fluorouracil in the rat hippocampus by a mechanism of prevention rather than recovery
5-Fluorouracil (5-FU) is a cytostatic drug associated with chemotherapy-induced cognitive impairments that many cancer patients experience after treatment. Previous work in rodents has shown that 5-FU reduces hippocampal cell proliferation, a possible mechanism for the observed cognitive impairmen...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science
2012
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| Online Access: | http://eprints.nottingham.ac.uk/2430/ http://eprints.nottingham.ac.uk/2430/ http://eprints.nottingham.ac.uk/2430/ http://eprints.nottingham.ac.uk/2430/1/WigmoreFluoxetine.pdf |