COMT methylation as a potential peripheral biomarker of schizophrenia

Schizophrenia is a common debilitating neuropsychiatry disorder. Currently, absolute clinical criteria (DSM-V) are used for the diagnosis. Identification of prediction and therapeutic markers of schizophrenia could expedite the disease diagnosis and management. Catechol-O-methyltransferase (COMT) wh...

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Main Authors:	Abd. Rahim, Nour El Huda, Rahim Mohd, Nabil Fikri, Mohd Noor, Hanisah, Abdullah, Kartini, Ku Zaifah, Norsidah, A. Talib, Norlelawati
Format:	Conference or Workshop Item
Language:	English
Published:	2017
Subjects:	RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry RZ Other systems of medicine RZ400 Mental healing
Online Access:	http://irep.iium.edu.my/57642/ http://irep.iium.edu.my/57642/13/57642.pdf

id	iium-57642
recordtype	eprints
spelling	iium-576422017-08-01T08:26:27Z http://irep.iium.edu.my/57642/ COMT methylation as a potential peripheral biomarker of schizophrenia Abd. Rahim, Nour El Huda Rahim Mohd, Nabil Fikri Mohd Noor, Hanisah Abdullah, Kartini Ku Zaifah, Norsidah A. Talib, Norlelawati RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry RZ Other systems of medicine RZ400 Mental healing Schizophrenia is a common debilitating neuropsychiatry disorder. Currently, absolute clinical criteria (DSM-V) are used for the diagnosis. Identification of prediction and therapeutic markers of schizophrenia could expedite the disease diagnosis and management. Catechol-O-methyltransferase (COMT) which regulates catecholamine and cognitive function in the developing neurons has long been considered as one of the candidate genes of schizophrenia. Recent studies have discovered hypomethylation of the COMT gene in the brain of schizophrenia patients. Our study aims to assess the COMT DNA methylation in the peripheral blood, on the premises that there are global epigenetic changes and the changes in the peripheral blood mirrors the methylation changes of the brain in the schizophrenia patients and the healthy controls. 138 schizophrenia patients from the Psychiatry Clinic, Hospital Kuantan Ampuan Afzan, Kuantan Pahang and 132 matched healthy controls from Kuantan district were recruited. Genomic DNA from the peripheral blood was bisulfite converted and quantitatively measured for the COMT DNA methylation using the MethyLight Taqman® assay and normalized with the ALU reference control to give the percentage methylation ratio. We found a significant hypomethylation of COMT in schizophrenia as compared to the control group (p=0.000). The hypomethylation was also significant in males (p=0.002) and females (p=0.032). This study suggests that DNA methylation analysis of COMT can be a potential peripheral biomarker in schizophrenia. 2017-05 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/57642/13/57642.pdf Abd. Rahim, Nour El Huda and Rahim Mohd, Nabil Fikri and Mohd Noor, Hanisah and Abdullah, Kartini and Ku Zaifah, Norsidah and A. Talib, Norlelawati (2017) COMT methylation as a potential peripheral biomarker of schizophrenia. In: INFORMM's Second International Conference on Molecular Diagnostics & Biomarker Discovery, 3rd-4th May 2017, Penang. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry RZ Other systems of medicine RZ400 Mental healing
spellingShingle	RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry RZ Other systems of medicine RZ400 Mental healing Abd. Rahim, Nour El Huda Rahim Mohd, Nabil Fikri Mohd Noor, Hanisah Abdullah, Kartini Ku Zaifah, Norsidah A. Talib, Norlelawati COMT methylation as a potential peripheral biomarker of schizophrenia
description	Schizophrenia is a common debilitating neuropsychiatry disorder. Currently, absolute clinical criteria (DSM-V) are used for the diagnosis. Identification of prediction and therapeutic markers of schizophrenia could expedite the disease diagnosis and management. Catechol-O-methyltransferase (COMT) which regulates catecholamine and cognitive function in the developing neurons has long been considered as one of the candidate genes of schizophrenia. Recent studies have discovered hypomethylation of the COMT gene in the brain of schizophrenia patients. Our study aims to assess the COMT DNA methylation in the peripheral blood, on the premises that there are global epigenetic changes and the changes in the peripheral blood mirrors the methylation changes of the brain in the schizophrenia patients and the healthy controls. 138 schizophrenia patients from the Psychiatry Clinic, Hospital Kuantan Ampuan Afzan, Kuantan Pahang and 132 matched healthy controls from Kuantan district were recruited. Genomic DNA from the peripheral blood was bisulfite converted and quantitatively measured for the COMT DNA methylation using the MethyLight Taqman® assay and normalized with the ALU reference control to give the percentage methylation ratio. We found a significant hypomethylation of COMT in schizophrenia as compared to the control group (p=0.000). The hypomethylation was also significant in males (p=0.002) and females (p=0.032). This study suggests that DNA methylation analysis of COMT can be a potential peripheral biomarker in schizophrenia.
format	Conference or Workshop Item
author	Abd. Rahim, Nour El Huda Rahim Mohd, Nabil Fikri Mohd Noor, Hanisah Abdullah, Kartini Ku Zaifah, Norsidah A. Talib, Norlelawati
author_facet	Abd. Rahim, Nour El Huda Rahim Mohd, Nabil Fikri Mohd Noor, Hanisah Abdullah, Kartini Ku Zaifah, Norsidah A. Talib, Norlelawati
author_sort	Abd. Rahim, Nour El Huda
title	COMT methylation as a potential peripheral biomarker of schizophrenia
title_short	COMT methylation as a potential peripheral biomarker of schizophrenia
title_full	COMT methylation as a potential peripheral biomarker of schizophrenia
title_fullStr	COMT methylation as a potential peripheral biomarker of schizophrenia
title_full_unstemmed	COMT methylation as a potential peripheral biomarker of schizophrenia
title_sort	comt methylation as a potential peripheral biomarker of schizophrenia
publishDate	2017
url	http://irep.iium.edu.my/57642/ http://irep.iium.edu.my/57642/13/57642.pdf
first_indexed	2018-09-07T07:42:09Z
last_indexed	2018-09-07T07:42:09Z
_version_	1610933736385282048

COMT methylation as a potential peripheral biomarker of schizophrenia

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