Tgf-β stimulated glycosaminoglycan (GAG) biosynthetic gene expression in vascular smooth muscle cells

The pre-inflammatory stage of atherosclerosis is associated with proteoglycan glycosaminoglycan (GAG) chain hyperelongation that results in increased proteoglycan binding to low density lipoprotein (LDL). Transforming Growth Factor-β (TGF-β) is closely associated with atherosclerosis and mediates GA...

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Main Authors:	Rostam, Muhamad Ashraf, Piva, Terence J., Osman, Narin, Little, Peter J.
Format:	Conference or Workshop Item
Language:	English English
Published:	2013
Subjects:	R Medicine (General) RM Therapeutics. Pharmacology
Online Access:	http://irep.iium.edu.my/55300/ http://irep.iium.edu.my/55300/1/Print_Ashraf_AVBS%20Poster%20030913.pdf http://irep.iium.edu.my/55300/7/FINAL%20Program%20for%20AVBS_ANZMS%202013.pdf

id	iium-55300
recordtype	eprints
spelling	iium-553002017-04-25T04:12:25Z http://irep.iium.edu.my/55300/ Tgf-β stimulated glycosaminoglycan (GAG) biosynthetic gene expression in vascular smooth muscle cells Rostam, Muhamad Ashraf Piva, Terence J. Osman, Narin Little, Peter J. R Medicine (General) RM Therapeutics. Pharmacology The pre-inflammatory stage of atherosclerosis is associated with proteoglycan glycosaminoglycan (GAG) chain hyperelongation that results in increased proteoglycan binding to low density lipoprotein (LDL). Transforming Growth Factor-β (TGF-β) is closely associated with atherosclerosis and mediates GAG chain hyperelongation.TGF-β signals through phosphorylation of Smad 2/3 at its C-terminus and it can also activate other kinases to phosphorylate Smad in the linker region. In vascular smooth muscle cells (VSMC) GAG chain hyperelongation is dependent upon transcription and translation but the targets of TGF-β signalling, most likely genes for GAG enzymes, remain unknown. A recent study by Anggraeni et al showed that GAG enzymes C4ST-1 and ChGn-2 involved in chondroitin sulphate (CS) GAG elongation have higher levels of expression in a mouse model of atherosclerosis. 2013-09-05 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/55300/1/Print_Ashraf_AVBS%20Poster%20030913.pdf application/pdf en http://irep.iium.edu.my/55300/7/FINAL%20Program%20for%20AVBS_ANZMS%202013.pdf Rostam, Muhamad Ashraf and Piva, Terence J. and Osman, Narin and Little, Peter J. (2013) Tgf-β stimulated glycosaminoglycan (GAG) biosynthetic gene expression in vascular smooth muscle cells. In: The 2013 Joint Meeting of AVBS & ANZMS, 5th-8th Sept. 2013, Novotel Resort, Barossa Valley, South Australia, Australia. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	R Medicine (General) RM Therapeutics. Pharmacology
spellingShingle	R Medicine (General) RM Therapeutics. Pharmacology Rostam, Muhamad Ashraf Piva, Terence J. Osman, Narin Little, Peter J. Tgf-β stimulated glycosaminoglycan (GAG) biosynthetic gene expression in vascular smooth muscle cells
description	The pre-inflammatory stage of atherosclerosis is associated with proteoglycan glycosaminoglycan (GAG) chain hyperelongation that results in increased proteoglycan binding to low density lipoprotein (LDL). Transforming Growth Factor-β (TGF-β) is closely associated with atherosclerosis and mediates GAG chain hyperelongation.TGF-β signals through phosphorylation of Smad 2/3 at its C-terminus and it can also activate other kinases to phosphorylate Smad in the linker region. In vascular smooth muscle cells (VSMC) GAG chain hyperelongation is dependent upon transcription and translation but the targets of TGF-β signalling, most likely genes for GAG enzymes, remain unknown. A recent study by Anggraeni et al showed that GAG enzymes C4ST-1 and ChGn-2 involved in chondroitin sulphate (CS) GAG elongation have higher levels of expression in a mouse model of atherosclerosis.
format	Conference or Workshop Item
author	Rostam, Muhamad Ashraf Piva, Terence J. Osman, Narin Little, Peter J.
author_facet	Rostam, Muhamad Ashraf Piva, Terence J. Osman, Narin Little, Peter J.
author_sort	Rostam, Muhamad Ashraf
title	Tgf-β stimulated glycosaminoglycan (GAG) biosynthetic gene expression in vascular smooth muscle cells
title_short	Tgf-β stimulated glycosaminoglycan (GAG) biosynthetic gene expression in vascular smooth muscle cells
title_full	Tgf-β stimulated glycosaminoglycan (GAG) biosynthetic gene expression in vascular smooth muscle cells
title_fullStr	Tgf-β stimulated glycosaminoglycan (GAG) biosynthetic gene expression in vascular smooth muscle cells
title_full_unstemmed	Tgf-β stimulated glycosaminoglycan (GAG) biosynthetic gene expression in vascular smooth muscle cells
title_sort	tgf-β stimulated glycosaminoglycan (gag) biosynthetic gene expression in vascular smooth muscle cells
publishDate	2013
url	http://irep.iium.edu.my/55300/ http://irep.iium.edu.my/55300/1/Print_Ashraf_AVBS%20Poster%20030913.pdf http://irep.iium.edu.my/55300/7/FINAL%20Program%20for%20AVBS_ANZMS%202013.pdf
first_indexed	2018-09-07T07:29:12Z
last_indexed	2018-09-07T07:29:12Z
_version_	1610932921960497152

Tgf-β stimulated glycosaminoglycan (GAG) biosynthetic gene expression in vascular smooth muscle cells

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