Vaccination: potential adverse effects and future challenges
Concerns over potential adverse effects of vaccination have been raised with the aim to develop and design efficient yet harmless vaccines. Using data derived from the reported vaccine efficiency trials and related research, we have analyzed the possible changes in homeostasis of the haematopoieti...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Kulliyyah of Science, IIUM
2011
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/29726/ http://irep.iium.edu.my/29726/ http://irep.iium.edu.my/29726/1/Vaccination.pdf |
| Summary: | Concerns over potential adverse effects of vaccination have been raised with the aim to develop and design
efficient yet harmless vaccines. Using data derived from the reported vaccine efficiency trials and related
research, we have analyzed the possible changes in homeostasis of the haematopoietic system in terms of level
of antibody (Ab) after vaccination. Several vaccines were reported to increase a wide range of total Ab
concentration such as <0.01%-2.40% in children and 0.02%-1.65% in adults. Reported increased level of IgG
against Haemophilus influenza type-B was recorded as 605-1210 folds higher in children and 1226-2453 folds
higher in adults than the required protective levels. Similar changes were also observed for other vaccines.
Such increased level of total Abs at least theoretically can contribute to higher concentration of protein i.e.,
hyperproteinemia in blood. Since Ab is a polymer of amino acids; therefore hyperproteinemia due to increased
level of Ab may in turn affect pH and osmosis of the blood. Therefore, an optimum dose of vaccine(s) for
sufficient boost of immune mechanisms, rather than a dose required for highest efficiency, is recommended
before an individual is vaccinated. |
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