Microwave-assisted synthesis of sec/tert-butyl 2-arylbenzimidazoles and their unexpected antiproliferative activity towards ER negative breast cancer cells

Microwave-assisted synthesis of sec/tert-butyl 2-arylbenzimidazoles and their unexpected antiproliferative activity towards ER negative breast cancer cells

A new series of N-sec/tert-butyl 2-arylbenzimidazole derivatives was synthesised in 85–96% yields within 2–3.5 min by condensing ethyl 3-amino-4-butylamino benzoate with various substituted metabisulfite adducts of benzaldehyde under focused microwave irradiation. The benzimidazole analogues were ch...

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Bibliographic Details
Main Authors: Abdul Rahim, Aisyah Saad, Muhamad Salhimi, Salizawati, Natarajan, Arumugam, Lim, Chung Pin, Ng, Shy Yee, Muttiah, Nithya Niranjini, Wong , Boon Keat, Abd Hamid, Shafida, Osman, Hasnah, Mat, Ishak
Format: Article
Language:English
Published: Informa UK, Ltd. 2013
Subjects:
QD Chemistry
RS Pharmacy and materia medica
Online Access:http://irep.iium.edu.my/29457/
http://irep.iium.edu.my/29457/
http://irep.iium.edu.my/29457/
http://irep.iium.edu.my/29457/4/JEnxInhibition.pdf

Internet

http://irep.iium.edu.my/29457/
http://irep.iium.edu.my/29457/
http://irep.iium.edu.my/29457/
http://irep.iium.edu.my/29457/4/JEnxInhibition.pdf

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