The use of modified polymeric polyhipe as an immobilized cell matrix
Utilization of modified-polyHIPE polymer matrix in the immobilization cell system is probably can substitute conventional cell matrix. The confined microenvironment was designed to promote the bacterium growth and its metabolic activity. The applied forced-flow seeding technique yielded a more un...
| Main Authors: | , |
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| Format: | Book Chapter |
| Language: | English |
| Published: |
IIUM Press
2011
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/20993/ http://irep.iium.edu.my/20993/ http://irep.iium.edu.my/20993/1/the_use_of_modified_-_C37.pdf |
| Summary: | Utilization of modified-polyHIPE polymer matrix in the immobilization cell system is
probably can substitute conventional cell matrix. The confined microenvironment was
designed to promote the bacterium growth and its metabolic activity. The applied forced-flow
seeding technique yielded a more uniform distribution of cells within the polymeric support,
which also helps to improve nutrient transport. This also prevents significant growth of cells
around the outer surface of matrix. The microstructure of the matrix with respect to its
physico-chemical characteristics, which include appropriate pore and interconnect sizes as
well as surface chemistry (i.e. hydrophobic, hydrophilic), are very important with respect to
the flow of nutrients and waste material and also for cell migration. As a result, the developed
immobilized matrix can be performed effectively and essential in the area of bioprocess
development specifically for microbial fermentations. |
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