Health-related quality of life profile in relation to chemotherapy-induced nausea and vomiting among breast cancer patients

Objective: Despite the availability of modern anti-emetics, chemotherapy-induced nausea and vomiting (CINV) symptoms remain distressing to a high number of cancer patients. This study intended to (1) describe the incidence of CINV and anti-emetic usage; (2) assess the health-related quality of life...

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Main Authors:	Pei, Lin Lua, Zakaria, Noor Salihah, Mamat, Nik Mazlan
Format:	Article
Language:	English English
Published:	ASEAN Federation of Psychiatry 2012
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/18737/ http://irep.iium.edu.my/18737/ http://irep.iium.edu.my/18737/6/Health_Related_Quality_of_Life_Profile.pdf http://irep.iium.edu.my/18737/8/Suhana_ASEAN_87-292-1-RV.pdf

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spelling	iium-187372013-12-06T08:18:53Z http://irep.iium.edu.my/18737/ Health-related quality of life profile in relation to chemotherapy-induced nausea and vomiting among breast cancer patients Pei, Lin Lua Zakaria, Noor Salihah Mamat, Nik Mazlan RS Pharmacy and materia medica Objective: Despite the availability of modern anti-emetics, chemotherapy-induced nausea and vomiting (CINV) symptoms remain distressing to a high number of cancer patients. This study intended to (1) describe the incidence of CINV and anti-emetic usage; (2) assess the health-related quality of life (HRQoL) and correlate its components with Global Health Status; (3) evaluate HRQoL status in relation to CINV among breast cancer patients receiving chemotherapy. Methods: A cross sectional study was conducted in two government hospitals located in the East Coast of Peninsular Malaysia (Terengganu, Kelantan). The Morrow Assessment of Nausea and Emesis Follow-up (MANE-FU) and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) were administered. Descriptive statistics and non-parametric tests were employed (SPSS 16). Results: Respondents included 41 female patients (age = 49 ± 9.6 years; Malay = 92.7%; no family history of breast cancer = 68.3% and on moderately emetogenic chemotherapy = 97.6%). Majority of patients experienced nausea during or after chemotherapy (90.2%) and rated it as ‘severe’. Most patients had taken anti-emetic (87.8%) and considered it ‘somewhat useful’. The median score for Global Health Status was 50 (IqR= 16.7). Emotional Functioning, Fatigue and Pain correlated fairly with HRQoL (rs= +0.435; -0.417; -0.387 respectively). Patients with ‘a lot’ and ‘moderate’ nausea displayed significantly more fatigue compared to those with little nausea (p=0.029). Those who experienced vomiting reported worse HRQoL profile compared to those who did not (p=0.011). Conclusion: These findings generally ascertained that CINV remains poorly controlled and significantly interferes with HRQoL, providing rooms for improvements in therapeutic intervention. ASEAN Federation of Psychiatry 2012-06 Article PeerReviewed application/pdf en http://irep.iium.edu.my/18737/6/Health_Related_Quality_of_Life_Profile.pdf application/pdf en http://irep.iium.edu.my/18737/8/Suhana_ASEAN_87-292-1-RV.pdf Pei, Lin Lua and Zakaria, Noor Salihah and Mamat, Nik Mazlan (2012) Health-related quality of life profile in relation to chemotherapy-induced nausea and vomiting among breast cancer patients. ASEAN Journal of Psychiatry, 13 (1). pp. 3-12. ISSN 2231-7805 (P) 2231-7791 (O) http://www.aseanjournalofpsychiatry.org/index.php/aseanjournalofpsychiatry/article/view/70
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Pei, Lin Lua Zakaria, Noor Salihah Mamat, Nik Mazlan Health-related quality of life profile in relation to chemotherapy-induced nausea and vomiting among breast cancer patients
description	Objective: Despite the availability of modern anti-emetics, chemotherapy-induced nausea and vomiting (CINV) symptoms remain distressing to a high number of cancer patients. This study intended to (1) describe the incidence of CINV and anti-emetic usage; (2) assess the health-related quality of life (HRQoL) and correlate its components with Global Health Status; (3) evaluate HRQoL status in relation to CINV among breast cancer patients receiving chemotherapy. Methods: A cross sectional study was conducted in two government hospitals located in the East Coast of Peninsular Malaysia (Terengganu, Kelantan). The Morrow Assessment of Nausea and Emesis Follow-up (MANE-FU) and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) were administered. Descriptive statistics and non-parametric tests were employed (SPSS 16). Results: Respondents included 41 female patients (age = 49 ± 9.6 years; Malay = 92.7%; no family history of breast cancer = 68.3% and on moderately emetogenic chemotherapy = 97.6%). Majority of patients experienced nausea during or after chemotherapy (90.2%) and rated it as ‘severe’. Most patients had taken anti-emetic (87.8%) and considered it ‘somewhat useful’. The median score for Global Health Status was 50 (IqR= 16.7). Emotional Functioning, Fatigue and Pain correlated fairly with HRQoL (rs= +0.435; -0.417; -0.387 respectively). Patients with ‘a lot’ and ‘moderate’ nausea displayed significantly more fatigue compared to those with little nausea (p=0.029). Those who experienced vomiting reported worse HRQoL profile compared to those who did not (p=0.011). Conclusion: These findings generally ascertained that CINV remains poorly controlled and significantly interferes with HRQoL, providing rooms for improvements in therapeutic intervention.
format	Article
author	Pei, Lin Lua Zakaria, Noor Salihah Mamat, Nik Mazlan
author_facet	Pei, Lin Lua Zakaria, Noor Salihah Mamat, Nik Mazlan
author_sort	Pei, Lin Lua
title	Health-related quality of life profile in relation to chemotherapy-induced nausea and vomiting among breast cancer patients
title_short	Health-related quality of life profile in relation to chemotherapy-induced nausea and vomiting among breast cancer patients
title_full	Health-related quality of life profile in relation to chemotherapy-induced nausea and vomiting among breast cancer patients
title_fullStr	Health-related quality of life profile in relation to chemotherapy-induced nausea and vomiting among breast cancer patients
title_full_unstemmed	Health-related quality of life profile in relation to chemotherapy-induced nausea and vomiting among breast cancer patients
title_sort	health-related quality of life profile in relation to chemotherapy-induced nausea and vomiting among breast cancer patients
publisher	ASEAN Federation of Psychiatry
publishDate	2012
url	http://irep.iium.edu.my/18737/ http://irep.iium.edu.my/18737/ http://irep.iium.edu.my/18737/6/Health_Related_Quality_of_Life_Profile.pdf http://irep.iium.edu.my/18737/8/Suhana_ASEAN_87-292-1-RV.pdf
first_indexed	2018-09-07T04:11:10Z
last_indexed	2018-09-07T04:11:10Z
_version_	1610920461987741696

Health-related quality of life profile in relation to chemotherapy-induced nausea and vomiting among breast cancer patients

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