THE EFFICACY OF HIGH-DOSE SIMVASTATIN IN ACUTE PERIOD OF ISCHEMIC STROKE

Aim. To estimate in a 12-month study mortality and frequency of recurrent cardiovascular events, dynamics of neurological deficit and endothelial dysfunction in patients with the first-time ischemic stroke treated with simvastatin 40 mg/day in acute period of the disease. Materials and methods. The...

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Main Authors:	V. V. Yakusevich, A. Yu. Malygin, S. V. Lychenko, A. S. Petrochenko, A. V. Kabanov
Format:	Article
Language:	English
Published:	Stolichnaya Izdatelskaya Kompaniya 2012-01-01
Series:	Racionalʹnaâ Farmakoterapiâ v Kardiologii
Subjects:	ischemic stroke simvastatin high dose endothelial dysfunction cardiovascular events
Online Access:	http://www.rpcardio.com/jour/article/view/393

id	doaj-art-f45525b2371346238fdbe1b0c223d45b
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spelling	doaj-art-f45525b2371346238fdbe1b0c223d45b2018-09-05T21:37:11ZengStolichnaya Izdatelskaya KompaniyaRacionalʹnaâ Farmakoterapiâ v Kardiologii1819-64462225-36532012-01-018141610.20996/1819-6446-2012-8-1-4-16393THE EFFICACY OF HIGH-DOSE SIMVASTATIN IN ACUTE PERIOD OF ISCHEMIC STROKEV. V. Yakusevich0A. Yu. Malygin1S. V. Lychenko2A. S. Petrochenko3A. V. Kabanov4Yaroslavl State Medical AcademyYaroslavl Municipal Clinical Hospital №8Yaroslavl State Medical AcademyYaroslavl State Medical AcademyYaroslavl State Medical AcademyAim. To estimate in a 12-month study mortality and frequency of recurrent cardiovascular events, dynamics of neurological deficit and endothelial dysfunction in patients with the first-time ischemic stroke treated with simvastatin 40 mg/day in acute period of the disease. Materials and methods. The efficacy of high-dose simvastatin (40 mg/day) therapy initiated in acute stage of ischemic stroke was evaluated in 12-month comparative randomized study. Patients of the first group (n=97) received standard stroke therapy , and patients of the second group (n=86) also received standard treatment and simvastatin additionally. Combined endpoint (cardiovascular death + recurrent cardiovascular events + necessity of readmission), dynamics of neurological status and endothelial function were considered. Results. Primary combined endpoint was achieved in 66 cases in the first group (68.04%) and in 47 (54.65%) in the second one (p=0.043). Neurological status evaluated by National Institutes of Health Stroke Scale (NIHSS), Mini-Mental State Examination (MMSE) scale, and Scandinavian scales had a faster positive dynamics in patients receiving simvastatin. The same patients revealed more intense and quick decrease in desquamated plasma endotheliocytes. Conclusion. Simvastatin 40 mg/day prescribed along with neuroprotective and antihypertensive treatment in acute stage of ischemic stroke leads to lowering of recurrent cardiovascular events number, positive dynamics of neurological status, regression of endothelial dysfunction reflected by significant decrease in number of circulating desquamated endotheliocytes.http://www.rpcardio.com/jour/article/view/393ischemic strokesimvastatinhigh doseendothelial dysfunctioncardiovascular events
institution	Open Data Bank
collection	Open Access Journals
building	Directory of Open Access Journals
language	English
format	Article
author	V. V. Yakusevich A. Yu. Malygin S. V. Lychenko A. S. Petrochenko A. V. Kabanov
spellingShingle	V. V. Yakusevich A. Yu. Malygin S. V. Lychenko A. S. Petrochenko A. V. Kabanov THE EFFICACY OF HIGH-DOSE SIMVASTATIN IN ACUTE PERIOD OF ISCHEMIC STROKE Racionalʹnaâ Farmakoterapiâ v Kardiologii ischemic stroke simvastatin high dose endothelial dysfunction cardiovascular events
author_facet	V. V. Yakusevich A. Yu. Malygin S. V. Lychenko A. S. Petrochenko A. V. Kabanov
author_sort	V. V. Yakusevich
title	THE EFFICACY OF HIGH-DOSE SIMVASTATIN IN ACUTE PERIOD OF ISCHEMIC STROKE
title_short	THE EFFICACY OF HIGH-DOSE SIMVASTATIN IN ACUTE PERIOD OF ISCHEMIC STROKE
title_full	THE EFFICACY OF HIGH-DOSE SIMVASTATIN IN ACUTE PERIOD OF ISCHEMIC STROKE
title_fullStr	THE EFFICACY OF HIGH-DOSE SIMVASTATIN IN ACUTE PERIOD OF ISCHEMIC STROKE
title_full_unstemmed	THE EFFICACY OF HIGH-DOSE SIMVASTATIN IN ACUTE PERIOD OF ISCHEMIC STROKE
title_sort	efficacy of high-dose simvastatin in acute period of ischemic stroke
publisher	Stolichnaya Izdatelskaya Kompaniya
series	Racionalʹnaâ Farmakoterapiâ v Kardiologii
issn	1819-6446 2225-3653
publishDate	2012-01-01
description	Aim. To estimate in a 12-month study mortality and frequency of recurrent cardiovascular events, dynamics of neurological deficit and endothelial dysfunction in patients with the first-time ischemic stroke treated with simvastatin 40 mg/day in acute period of the disease. Materials and methods. The efficacy of high-dose simvastatin (40 mg/day) therapy initiated in acute stage of ischemic stroke was evaluated in 12-month comparative randomized study. Patients of the first group (n=97) received standard stroke therapy , and patients of the second group (n=86) also received standard treatment and simvastatin additionally. Combined endpoint (cardiovascular death + recurrent cardiovascular events + necessity of readmission), dynamics of neurological status and endothelial function were considered. Results. Primary combined endpoint was achieved in 66 cases in the first group (68.04%) and in 47 (54.65%) in the second one (p=0.043). Neurological status evaluated by National Institutes of Health Stroke Scale (NIHSS), Mini-Mental State Examination (MMSE) scale, and Scandinavian scales had a faster positive dynamics in patients receiving simvastatin. The same patients revealed more intense and quick decrease in desquamated plasma endotheliocytes. Conclusion. Simvastatin 40 mg/day prescribed along with neuroprotective and antihypertensive treatment in acute stage of ischemic stroke leads to lowering of recurrent cardiovascular events number, positive dynamics of neurological status, regression of endothelial dysfunction reflected by significant decrease in number of circulating desquamated endotheliocytes.
topic	ischemic stroke simvastatin high dose endothelial dysfunction cardiovascular events
url	http://www.rpcardio.com/jour/article/view/393
_version_	1612615875084419072

THE EFFICACY OF HIGH-DOSE SIMVASTATIN IN ACUTE PERIOD OF ISCHEMIC STROKE

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