Retrograde axonal transport of rabies virus is unaffected by interferon treatment but blocked by emetine locally in axons.

Retrograde axonal transport of rabies virus is unaffected by interferon treatment but blocked by emetine locally in axons.

Neuroinvasive viruses, such as alpha herpesviruses (αHV) and rabies virus (RABV), initially infect peripheral tissues, followed by invasion of the innervating axon termini. Virus particles must undergo long distance retrograde axonal transport to reach the neuron cell bodies in the peripheral or cen...

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Bibliographic Details
Main Authors: Margaret A MacGibeny, Orkide O Koyuncu, Christoph Wirblich, Matthias J Schnell, Lynn W Enquist
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-07-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC6070286?pdf=render

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http://europepmc.org/articles/PMC6070286?pdf=render

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