Relationship between threatened miscarriage and gestational diabetes mellitus

Abstract Background Both threatened miscarriage and gestational diabetes mellitus (GDM) are common complications of pregnancy. However, only one pilot study has reported that these complications are not related. We aimed to investigate whether threatened miscarriage is one of the risk factors of GDM...

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Main Authors:	Hee Joong Lee, Errol Norwitz, Banghyun Lee
Format:	Article
Language:	English
Published:	BioMed Central 2018-08-01
Series:	BMC Pregnancy and Childbirth
Subjects:	Gestational diabetes mellitus Threatened miscarriage Borderline GDM Maternal hyperglycemia
Online Access:	http://link.springer.com/article/10.1186/s12884-018-1955-2

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spelling	doaj-art-f1b1e192b70b4516bcb23403abc2f6522018-08-15T23:55:21ZengBioMed CentralBMC Pregnancy and Childbirth1471-23932018-08-011811810.1186/s12884-018-1955-2Relationship between threatened miscarriage and gestational diabetes mellitusHee Joong Lee0Errol Norwitz1Banghyun Lee2Department of Obstetrics & Gynecology, College of Medicine, The Catholic University of KoreaDepartment of Obstetrics & Gynecology, Tufts University School of MedicineDepartment of Obstetrics and Gynecology, Hallym University Kangdong Sacred Heart HospitalAbstract Background Both threatened miscarriage and gestational diabetes mellitus (GDM) are common complications of pregnancy. However, only one pilot study has reported that these complications are not related. We aimed to investigate whether threatened miscarriage is one of the risk factors of GDM. Methods An unmatched case-control study of 1567 pregnant Korean women who underwent a two-step approach to diagnose GDM was retrospectively conducted. The eligible women were classified into normal (n = 840), borderline GDM (n = 480), and GDM (n = 247) groups. We analyzed the associations with threatened miscarriage in all groups with adjustment for confounding factors. Results The proportion of women who experienced threatened miscarriage was significantly lower in the GDM group than in the normal group (adjusted odds ratio (OR), 0.38; 95% confidence interval (CI), 0.18–0.78). It was significantly lower in the maternal hyperglycemia group (borderline GDM and GDM groups) than in the normal group (adjusted OR, 0.66; 95% CI, 0.47–0.91). The proportion of women who experienced threatened miscarriage was also significantly lower in the GDM group than in the normal (adjusted OR, 0.35; 95% CI, 0.17–0.70) and borderline GDM groups (adjusted OR, 0.46; 95% CI, 0.22–0.94). Moreover, the proportion of women who experienced threatened miscarriage significantly decreased according to the severity of glucose intolerance (adjusted OR, 0.94; 95% CI, 0.76–1.16). Conclusion This study demonstrates that threatened miscarriage is associated with decreased risk of GDM and the severity of glucose intolerance in Korean women. Additional studies are warranted to understand the pathophysiologic mechanisms that might exist between these frequent complications of pregnancy.http://link.springer.com/article/10.1186/s12884-018-1955-2Gestational diabetes mellitusThreatened miscarriageBorderline GDMMaternal hyperglycemia
institution	Open Data Bank
collection	Open Access Journals
building	Directory of Open Access Journals
language	English
format	Article
author	Hee Joong Lee Errol Norwitz Banghyun Lee
spellingShingle	Hee Joong Lee Errol Norwitz Banghyun Lee Relationship between threatened miscarriage and gestational diabetes mellitus BMC Pregnancy and Childbirth Gestational diabetes mellitus Threatened miscarriage Borderline GDM Maternal hyperglycemia
author_facet	Hee Joong Lee Errol Norwitz Banghyun Lee
author_sort	Hee Joong Lee
title	Relationship between threatened miscarriage and gestational diabetes mellitus
title_short	Relationship between threatened miscarriage and gestational diabetes mellitus
title_full	Relationship between threatened miscarriage and gestational diabetes mellitus
title_fullStr	Relationship between threatened miscarriage and gestational diabetes mellitus
title_full_unstemmed	Relationship between threatened miscarriage and gestational diabetes mellitus
title_sort	relationship between threatened miscarriage and gestational diabetes mellitus
publisher	BioMed Central
series	BMC Pregnancy and Childbirth
issn	1471-2393
publishDate	2018-08-01
description	Abstract Background Both threatened miscarriage and gestational diabetes mellitus (GDM) are common complications of pregnancy. However, only one pilot study has reported that these complications are not related. We aimed to investigate whether threatened miscarriage is one of the risk factors of GDM. Methods An unmatched case-control study of 1567 pregnant Korean women who underwent a two-step approach to diagnose GDM was retrospectively conducted. The eligible women were classified into normal (n = 840), borderline GDM (n = 480), and GDM (n = 247) groups. We analyzed the associations with threatened miscarriage in all groups with adjustment for confounding factors. Results The proportion of women who experienced threatened miscarriage was significantly lower in the GDM group than in the normal group (adjusted odds ratio (OR), 0.38; 95% confidence interval (CI), 0.18–0.78). It was significantly lower in the maternal hyperglycemia group (borderline GDM and GDM groups) than in the normal group (adjusted OR, 0.66; 95% CI, 0.47–0.91). The proportion of women who experienced threatened miscarriage was also significantly lower in the GDM group than in the normal (adjusted OR, 0.35; 95% CI, 0.17–0.70) and borderline GDM groups (adjusted OR, 0.46; 95% CI, 0.22–0.94). Moreover, the proportion of women who experienced threatened miscarriage significantly decreased according to the severity of glucose intolerance (adjusted OR, 0.94; 95% CI, 0.76–1.16). Conclusion This study demonstrates that threatened miscarriage is associated with decreased risk of GDM and the severity of glucose intolerance in Korean women. Additional studies are warranted to understand the pathophysiologic mechanisms that might exist between these frequent complications of pregnancy.
topic	Gestational diabetes mellitus Threatened miscarriage Borderline GDM Maternal hyperglycemia
url	http://link.springer.com/article/10.1186/s12884-018-1955-2
_version_	1612698982618759168

Relationship between threatened miscarriage and gestational diabetes mellitus

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