Relationship between threatened miscarriage and gestational diabetes mellitus

Abstract Background Both threatened miscarriage and gestational diabetes mellitus (GDM) are common complications of pregnancy. However, only one pilot study has reported that these complications are not related. We aimed to investigate whether threatened miscarriage is one of the risk factors of GDM...

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Main Authors: Hee Joong Lee, Errol Norwitz, Banghyun Lee
Format: Article
Language:English
Published: BioMed Central 2018-08-01
Series:BMC Pregnancy and Childbirth
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12884-018-1955-2
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spelling doaj-art-f1b1e192b70b4516bcb23403abc2f6522018-08-15T23:55:21ZengBioMed CentralBMC Pregnancy and Childbirth1471-23932018-08-011811810.1186/s12884-018-1955-2Relationship between threatened miscarriage and gestational diabetes mellitusHee Joong Lee0Errol Norwitz1Banghyun Lee2Department of Obstetrics & Gynecology, College of Medicine, The Catholic University of KoreaDepartment of Obstetrics & Gynecology, Tufts University School of MedicineDepartment of Obstetrics and Gynecology, Hallym University Kangdong Sacred Heart HospitalAbstract Background Both threatened miscarriage and gestational diabetes mellitus (GDM) are common complications of pregnancy. However, only one pilot study has reported that these complications are not related. We aimed to investigate whether threatened miscarriage is one of the risk factors of GDM. Methods An unmatched case-control study of 1567 pregnant Korean women who underwent a two-step approach to diagnose GDM was retrospectively conducted. The eligible women were classified into normal (n = 840), borderline GDM (n = 480), and GDM (n = 247) groups. We analyzed the associations with threatened miscarriage in all groups with adjustment for confounding factors. Results The proportion of women who experienced threatened miscarriage was significantly lower in the GDM group than in the normal group (adjusted odds ratio (OR), 0.38; 95% confidence interval (CI), 0.18–0.78). It was significantly lower in the maternal hyperglycemia group (borderline GDM and GDM groups) than in the normal group (adjusted OR, 0.66; 95% CI, 0.47–0.91). The proportion of women who experienced threatened miscarriage was also significantly lower in the GDM group than in the normal (adjusted OR, 0.35; 95% CI, 0.17–0.70) and borderline GDM groups (adjusted OR, 0.46; 95% CI, 0.22–0.94). Moreover, the proportion of women who experienced threatened miscarriage significantly decreased according to the severity of glucose intolerance (adjusted OR, 0.94; 95% CI, 0.76–1.16). Conclusion This study demonstrates that threatened miscarriage is associated with decreased risk of GDM and the severity of glucose intolerance in Korean women. Additional studies are warranted to understand the pathophysiologic mechanisms that might exist between these frequent complications of pregnancy.http://link.springer.com/article/10.1186/s12884-018-1955-2Gestational diabetes mellitusThreatened miscarriageBorderline GDMMaternal hyperglycemia
institution Open Data Bank
collection Open Access Journals
building Directory of Open Access Journals
language English
format Article
author Hee Joong Lee
Errol Norwitz
Banghyun Lee
spellingShingle Hee Joong Lee
Errol Norwitz
Banghyun Lee
Relationship between threatened miscarriage and gestational diabetes mellitus
BMC Pregnancy and Childbirth
Gestational diabetes mellitus
Threatened miscarriage
Borderline GDM
Maternal hyperglycemia
author_facet Hee Joong Lee
Errol Norwitz
Banghyun Lee
author_sort Hee Joong Lee
title Relationship between threatened miscarriage and gestational diabetes mellitus
title_short Relationship between threatened miscarriage and gestational diabetes mellitus
title_full Relationship between threatened miscarriage and gestational diabetes mellitus
title_fullStr Relationship between threatened miscarriage and gestational diabetes mellitus
title_full_unstemmed Relationship between threatened miscarriage and gestational diabetes mellitus
title_sort relationship between threatened miscarriage and gestational diabetes mellitus
publisher BioMed Central
series BMC Pregnancy and Childbirth
issn 1471-2393
publishDate 2018-08-01
description Abstract Background Both threatened miscarriage and gestational diabetes mellitus (GDM) are common complications of pregnancy. However, only one pilot study has reported that these complications are not related. We aimed to investigate whether threatened miscarriage is one of the risk factors of GDM. Methods An unmatched case-control study of 1567 pregnant Korean women who underwent a two-step approach to diagnose GDM was retrospectively conducted. The eligible women were classified into normal (n = 840), borderline GDM (n = 480), and GDM (n = 247) groups. We analyzed the associations with threatened miscarriage in all groups with adjustment for confounding factors. Results The proportion of women who experienced threatened miscarriage was significantly lower in the GDM group than in the normal group (adjusted odds ratio (OR), 0.38; 95% confidence interval (CI), 0.18–0.78). It was significantly lower in the maternal hyperglycemia group (borderline GDM and GDM groups) than in the normal group (adjusted OR, 0.66; 95% CI, 0.47–0.91). The proportion of women who experienced threatened miscarriage was also significantly lower in the GDM group than in the normal (adjusted OR, 0.35; 95% CI, 0.17–0.70) and borderline GDM groups (adjusted OR, 0.46; 95% CI, 0.22–0.94). Moreover, the proportion of women who experienced threatened miscarriage significantly decreased according to the severity of glucose intolerance (adjusted OR, 0.94; 95% CI, 0.76–1.16). Conclusion This study demonstrates that threatened miscarriage is associated with decreased risk of GDM and the severity of glucose intolerance in Korean women. Additional studies are warranted to understand the pathophysiologic mechanisms that might exist between these frequent complications of pregnancy.
topic Gestational diabetes mellitus
Threatened miscarriage
Borderline GDM
Maternal hyperglycemia
url http://link.springer.com/article/10.1186/s12884-018-1955-2
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