Dominant Negative FADD/MORT1 Inhibits the Development of Intestinal Intraepithelial Lymphocytes With a Marked Defect on CD8αα+TCRγδ+ T Cells

Dominant Negative FADD/MORT1 Inhibits the Development of Intestinal Intraepithelial Lymphocytes With a Marked Defect on CD8αα+TCRγδ+ T Cells

Intestinal intraepithelial lymphocytes (IELs) play a critical role in mucosal immune system, which differ from thymus-derived cells and develop locally in gut. Although the development of IELs has been studied in some detail, the molecular cues controlling their local development remain unclear. Her...

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Bibliographic Details
Main Authors: Xuerui Zhang, Lina Huo, Lulu Song, Zhaoqing Hu, Xinran Wang, Yuheng Han, Ying Wang, Peipei Xu, Jing Zhang, Zi-Chun Hua
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Immunology
Subjects:
FADD
mucosal immune system
γδ+ T-IELs
LPLs
DSS-induced colitis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02038/full

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