Alcohol-free essential oils containing mouthrinse efficacy on three-day supragingival plaque regrowth: a randomized crossover clinical trial

Alcohol-free essential oils containing mouthrinse efficacy on three-day supragingival plaque regrowth: a randomized crossover clinical trial

Abstract Background To evaluate the antiplaque effects of an alcohol-free mouthrinse containing essential oils—Listerine Zero (LZ)—and an alcohol-based essential oils mouthrinse (EO+) compared with a positive control of 0.20% chlorhexidine mouthrinse (CHX) and a negative control of a placebo solutio...

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Main Authors: Enrico Marchetti, Simona Tecco, Eleonora Caterini, Fabio Casalena, Vincenzo Quinzi, Antonella Mattei, Giuseppe Marzo
Format: Article
Language:English
Published: BioMed Central 2017-03-01
Series:Trials
Subjects:
Dental plaque
Mouthrinse
Essential oils
Alcohol-free
Chlorhexidine
Online Access:http://link.springer.com/article/10.1186/s13063-017-1901-z
id doaj-art-dcb197febcbb413a8372726192f23454
recordtype oai_dc
spelling doaj-art-dcb197febcbb413a8372726192f234542018-08-20T14:39:50ZengBioMed CentralTrials1745-62152017-03-011811810.1186/s13063-017-1901-zAlcohol-free essential oils containing mouthrinse efficacy on three-day supragingival plaque regrowth: a randomized crossover clinical trialEnrico Marchetti0Simona Tecco1Eleonora Caterini2Fabio Casalena3Vincenzo Quinzi4Antonella Mattei5Giuseppe Marzo6Department of Life, Health and Environmental Sciences, University of L’AquilaDental School University Vita-Salute San Raffaele, MilanoDepartment of Life, Health and Environmental Sciences, University of L’AquilaDepartment of Life, Health and Environmental Sciences, University of L’AquilaDepartment of Life, Health and Environmental Sciences, University of L’AquilaDepartment of Life, Health and Environmental Sciences, University of L’AquilaDepartment of Life, Health and Environmental Sciences, University of L’AquilaAbstract Background To evaluate the antiplaque effects of an alcohol-free mouthrinse containing essential oils—Listerine Zero (LZ)—and an alcohol-based essential oils mouthrinse (EO+) compared with a positive control of 0.20% chlorhexidine mouthrinse (CHX) and a negative control of a placebo solution (saline), using an in vivo plaque regrowth model of three days. Methods The study was designed as a double-masked, randomized, crossover clinical trial, involving 21 volunteers to compare four different mouthrinses, using a three-day plaque regrowth model. After receiving thorough professional prophylaxis at baseline, over the next three days each volunteer refrained from all oral hygiene measures and performed two daily rinses with 15 mL of the test mouthrinses. EO+ was compared with LZ. CHX rinse served as a positive control and a placebo solution as a negative control. At the end of each experimental period, the Plaque Index (PI) was assessed and a panelist completed through a visual analogue scale (VAS) questionnaire evaluating the organoleptic properties of each product. Each participant underwent a 14-day washout period and then there was another allocation. Results LZ showed the same inhibitory activity on plaque regrowth compared with EO+ in the whole mouth (PI = 1.72 versus 1.65, respectively), but there was less of an effect compared to the CHX (overall PI of 1.07) and a more efficient activity than the saline solution negative control (PI = 2.31). The difference of 0.07 between LZ and EO+ was not statistically significant. Conclusions LZ seems to have the same inhibiting effect on plaque regrowth as EO+ and a less inhibiting effect than the CHX control. Both LZ and EO+, as well as the CHX control, show a better inhibiting effect on plaque regrowth than the placebo solution. Trial registration ClinicalTrials.gov, NCT02894593 . Registered on 4 September 2016.http://link.springer.com/article/10.1186/s13063-017-1901-zDental plaqueMouthrinseEssential oilsAlcohol-freeChlorhexidine
institution Open Data Bank
collection Open Access Journals
building Directory of Open Access Journals
language English
format Article
author Enrico Marchetti
Simona Tecco
Eleonora Caterini
Fabio Casalena
Vincenzo Quinzi
Antonella Mattei
Giuseppe Marzo
spellingShingle Enrico Marchetti
Simona Tecco
Eleonora Caterini
Fabio Casalena
Vincenzo Quinzi
Antonella Mattei
Giuseppe Marzo
Alcohol-free essential oils containing mouthrinse efficacy on three-day supragingival plaque regrowth: a randomized crossover clinical trial
Trials
Dental plaque
Mouthrinse
Essential oils
Alcohol-free
Chlorhexidine
author_facet Enrico Marchetti
Simona Tecco
Eleonora Caterini
Fabio Casalena
Vincenzo Quinzi
Antonella Mattei
Giuseppe Marzo
author_sort Enrico Marchetti
title Alcohol-free essential oils containing mouthrinse efficacy on three-day supragingival plaque regrowth: a randomized crossover clinical trial
title_short Alcohol-free essential oils containing mouthrinse efficacy on three-day supragingival plaque regrowth: a randomized crossover clinical trial
title_full Alcohol-free essential oils containing mouthrinse efficacy on three-day supragingival plaque regrowth: a randomized crossover clinical trial
title_fullStr Alcohol-free essential oils containing mouthrinse efficacy on three-day supragingival plaque regrowth: a randomized crossover clinical trial
title_full_unstemmed Alcohol-free essential oils containing mouthrinse efficacy on three-day supragingival plaque regrowth: a randomized crossover clinical trial
title_sort alcohol-free essential oils containing mouthrinse efficacy on three-day supragingival plaque regrowth: a randomized crossover clinical trial
publisher BioMed Central
series Trials
issn 1745-6215
publishDate 2017-03-01
description Abstract Background To evaluate the antiplaque effects of an alcohol-free mouthrinse containing essential oils—Listerine Zero (LZ)—and an alcohol-based essential oils mouthrinse (EO+) compared with a positive control of 0.20% chlorhexidine mouthrinse (CHX) and a negative control of a placebo solution (saline), using an in vivo plaque regrowth model of three days. Methods The study was designed as a double-masked, randomized, crossover clinical trial, involving 21 volunteers to compare four different mouthrinses, using a three-day plaque regrowth model. After receiving thorough professional prophylaxis at baseline, over the next three days each volunteer refrained from all oral hygiene measures and performed two daily rinses with 15 mL of the test mouthrinses. EO+ was compared with LZ. CHX rinse served as a positive control and a placebo solution as a negative control. At the end of each experimental period, the Plaque Index (PI) was assessed and a panelist completed through a visual analogue scale (VAS) questionnaire evaluating the organoleptic properties of each product. Each participant underwent a 14-day washout period and then there was another allocation. Results LZ showed the same inhibitory activity on plaque regrowth compared with EO+ in the whole mouth (PI = 1.72 versus 1.65, respectively), but there was less of an effect compared to the CHX (overall PI of 1.07) and a more efficient activity than the saline solution negative control (PI = 2.31). The difference of 0.07 between LZ and EO+ was not statistically significant. Conclusions LZ seems to have the same inhibiting effect on plaque regrowth as EO+ and a less inhibiting effect than the CHX control. Both LZ and EO+, as well as the CHX control, show a better inhibiting effect on plaque regrowth than the placebo solution. Trial registration ClinicalTrials.gov, NCT02894593 . Registered on 4 September 2016.
topic Dental plaque
Mouthrinse
Essential oils
Alcohol-free
Chlorhexidine
url http://link.springer.com/article/10.1186/s13063-017-1901-z
_version_ 1612688780741836800

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