Neuronal Subtype Generation During Postnatal Olfactory Bulb Neurogenesis

In the perinatal and adult forebrain, regionalized neural stem cells lining the ventricular walls produce different types of olfactory bulb interneurons. Although these postnatal stem cells are lineage related to their embryonic counterparts that produce, for example, cortical, septal, and striatal...

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Main Authors:	Alexandra Angelova, Marie-Catherine Tiveron, Harold Cremer, Christophe Beclin
Format:	Article
Language:	English
Published:	SAGE Publishing 2018-02-01
Series:	Journal of Experimental Neuroscience
Online Access:	https://doi.org/10.1177/1179069518755670

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spelling	doaj-art-ccf28d973cd14b60a6fc6b43902b2b1e2018-08-20T17:02:37ZengSAGE PublishingJournal of Experimental Neuroscience1179-06952018-02-011210.1177/1179069518755670Neuronal Subtype Generation During Postnatal Olfactory Bulb NeurogenesisAlexandra AngelovaMarie-Catherine TiveronHarold CremerChristophe BeclinIn the perinatal and adult forebrain, regionalized neural stem cells lining the ventricular walls produce different types of olfactory bulb interneurons. Although these postnatal stem cells are lineage related to their embryonic counterparts that produce, for example, cortical, septal, and striatal neurons, their output at the level of neuronal phenotype changes dramatically. Tiveron et al. investigated the molecular determinants underlying stem cell regionalization and the gene expression changes inducing the shift from embryonic to adult neuron production. High-resolution gene expression analyses of different lineages revealed that the zinc finger proteins, Zic1 and Zic2, are postnatally induced in the dorsal olfactory bulb neuron lineage. Functional studies demonstrated that these factors confer a GABAergic and calretinin-positive phenotype to neural stem cells while repressing dopaminergic fate. Based on these findings, we discuss the molecular mechanisms that allow acquisition of new traits during the transition from embryonic to adult neurogenesis. We focus on the involvement of epigenetic marks and emphasize why the identification of master transcription factors, that instruct the fate of postnatally generated neurons, can help in deciphering the mechanisms driving fate transition from embryonic to adult neuron production.https://doi.org/10.1177/1179069518755670
institution	Open Data Bank
collection	Open Access Journals
building	Directory of Open Access Journals
language	English
format	Article
author	Alexandra Angelova Marie-Catherine Tiveron Harold Cremer Christophe Beclin
spellingShingle	Alexandra Angelova Marie-Catherine Tiveron Harold Cremer Christophe Beclin Neuronal Subtype Generation During Postnatal Olfactory Bulb Neurogenesis Journal of Experimental Neuroscience
author_facet	Alexandra Angelova Marie-Catherine Tiveron Harold Cremer Christophe Beclin
author_sort	Alexandra Angelova
title	Neuronal Subtype Generation During Postnatal Olfactory Bulb Neurogenesis
title_short	Neuronal Subtype Generation During Postnatal Olfactory Bulb Neurogenesis
title_full	Neuronal Subtype Generation During Postnatal Olfactory Bulb Neurogenesis
title_fullStr	Neuronal Subtype Generation During Postnatal Olfactory Bulb Neurogenesis
title_full_unstemmed	Neuronal Subtype Generation During Postnatal Olfactory Bulb Neurogenesis
title_sort	neuronal subtype generation during postnatal olfactory bulb neurogenesis
publisher	SAGE Publishing
series	Journal of Experimental Neuroscience
issn	1179-0695
publishDate	2018-02-01
description	In the perinatal and adult forebrain, regionalized neural stem cells lining the ventricular walls produce different types of olfactory bulb interneurons. Although these postnatal stem cells are lineage related to their embryonic counterparts that produce, for example, cortical, septal, and striatal neurons, their output at the level of neuronal phenotype changes dramatically. Tiveron et al. investigated the molecular determinants underlying stem cell regionalization and the gene expression changes inducing the shift from embryonic to adult neuron production. High-resolution gene expression analyses of different lineages revealed that the zinc finger proteins, Zic1 and Zic2, are postnatally induced in the dorsal olfactory bulb neuron lineage. Functional studies demonstrated that these factors confer a GABAergic and calretinin-positive phenotype to neural stem cells while repressing dopaminergic fate. Based on these findings, we discuss the molecular mechanisms that allow acquisition of new traits during the transition from embryonic to adult neurogenesis. We focus on the involvement of epigenetic marks and emphasize why the identification of master transcription factors, that instruct the fate of postnatally generated neurons, can help in deciphering the mechanisms driving fate transition from embryonic to adult neuron production.
url	https://doi.org/10.1177/1179069518755670
_version_	1612685647269593088

Neuronal Subtype Generation During Postnatal Olfactory Bulb Neurogenesis

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