Effect of ethanol extract of Trigonella foenum-graecum on gentamicin-induced nephrotoxicity in rat
<p class="Abstract">The present study was designed to determine the ameliorative effect of ethanol extract of <em>Trigonella foenum-graecum</em> in an experimental model of gentamicin-induced nephrotoxic rat. To induce nephrotoxicity, gentamicin was administered (80 mg/kg...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Bangabandhu Sheikh Mujib Medical University
2018-05-01
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| Series: | Bangabandhu Sheikh Mujib Medical University Journal |
| Subjects: | |
| Online Access: | https://188.42.129.20/index.php/BSMMUJ/article/view/35778 |
| Summary: | <p class="Abstract">The present study was designed to determine the ameliorative effect of ethanol extract of <em>Trigonella foenum-graecum</em> in an experimental model of gentamicin-induced nephrotoxic rat. To induce nephrotoxicity, gentamicin was administered (80 mg/kg/day for 7 days) intraperitoneally. The ethanol extract of <em>T. foenum-graecum</em> was administered (500 mg/kg/day) orally concomitantly with gentamicin for 21 days and 28 days in different groups. Biochemical indices i.e. serum creatinine and serum urea levels were estimated to determine nephrotoxicity and amelioration of nephrotoxicity in all groups. To determine the status of oxidative stress and lipid peroxidation, the renal cortical reduced glutathione and malondialdehyde levels were estimated. Changes in renal architecture were estimated by histopathology of renal tissues. Statistically significant amelioration was observed in all the biochemical parameters supported by significant improvement of renal cortical histology in <em>T. foenum-graecum</em>-treated groups.</p> |
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| ISSN: | 2074-2908 2224-7750 |