Linking hypoxia, DNA damage and proliferation in multicellular tumor spheroids

Linking hypoxia, DNA damage and proliferation in multicellular tumor spheroids

Abstract Background Multicellular Tumor Spheroids are frequently used to mimic the regionalization of proliferation and the hypoxic environment within avascular tumors. Here we exploit these features to study the activation of DNA damage repair pathways and their correlation to developing hypoxia. M...

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Bibliographic Details
Main Authors: Stephen Riffle, Ram Naresh Pandey, Morgan Albert, Rashmi S. Hegde
Format: Article
Language:English
Published: BioMed Central 2017-05-01
Series:BMC Cancer
Subjects:
Spheroid
Ewing sarcoma
DNA damage repair
ATM
ATR
Hypoxia
Online Access:http://link.springer.com/article/10.1186/s12885-017-3319-0

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http://link.springer.com/article/10.1186/s12885-017-3319-0

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