Development of a quadruple qRT-PCR assay for simultaneous identification of highly and low pathogenic H7N9 avian influenza viruses and characterization against oseltamivir resistance

Development of a quadruple qRT-PCR assay for simultaneous identification of highly and low pathogenic H7N9 avian influenza viruses and characterization against oseltamivir resistance

Abstract Background During the fifth wave of human H7N9 infections, a novel highly pathogenic (HP) H7N9 variant emerged with an insertion of multiple basic amino acids in the HA cleavage site. Moreover, a neuraminidase inhibitor (NAI) resistance (R292K in NA) mutation was found in H7N9 isolates from...

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Bibliographic Details
Main Authors: Yang Yang, Shanqin Li, Gary Wong, Sufang Ma, Zhixiang Xu, Xiaonan Zhao, Hong Li, Wen Xu, Haixia Zheng, Jingyan Lin, Qi Zhao, Wenjun Liu, Yingxia Liu, George F. Gao, Yuhai Bi
Format: Article
Language:English
Published: BioMed Central 2018-08-01
Series:BMC Infectious Diseases
Subjects:
Highly/low pathogenic avian influenza virus
H7N9
Quadruple qRT-PCR
Molecular diagnostics
NAI-resistance
Oseltamivir
Online Access:http://link.springer.com/article/10.1186/s12879-018-3302-7

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http://link.springer.com/article/10.1186/s12879-018-3302-7

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