Exosomes isolated from cancer patients’ sera transfer malignant traits and confer the same phenotype of primary tumors to oncosuppressor-mutated cells

Exosomes isolated from cancer patients’ sera transfer malignant traits and confer the same phenotype of primary tumors to oncosuppressor-mutated cells

Abstract Background Horizontal transfer of malignant traits from the primary tumor to distant organs, through blood circulating factors, has recently become a thoroughly studied metastatic pathway to explain cancer dissemination. Recently, we reported that oncosuppressor gene-mutated human cells und...

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Bibliographic Details
Main Authors: Mohamed Abdouh, Dana Hamam, Zu-Hua Gao, Vincenzo Arena, Manuel Arena, Goffredo Orazio Arena
Format: Article
Language:English
Published: BioMed Central 2017-08-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Cancer patients’ serum
Exosomes
Malignant transformation
Horizontal transfer
Tumor suppressor genes
Genometastasis
Online Access:http://link.springer.com/article/10.1186/s13046-017-0587-0

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http://link.springer.com/article/10.1186/s13046-017-0587-0

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