Effects of selexipag and its active metabolite in contrasting the profibrotic myofibroblast activity in cultured scleroderma skin fibroblasts

Effects of selexipag and its active metabolite in contrasting the profibrotic myofibroblast activity in cultured scleroderma skin fibroblasts

Abstract Background Myofibroblasts contribute to fibrosis through the overproduction of extracellular matrix (ECM) proteins, primarily type I collagen (COL-1) and fibronectin (FN), a process which is mediated in systemic sclerosis (SSc) by the activation of fibrogenic intracellular signaling transdu...

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Bibliographic Details
Main Authors: Maurizio Cutolo, Barbara Ruaro, Paola Montagna, Renata Brizzolara, Emanuela Stratta, Amelia Chiara Trombetta, Stefano Scabini, Pier Paolo Tavilla, Aurora Parodi, Claudio Corallo, Nicola Giordano, Sabrina Paolino, Carmen Pizzorni, Alberto Sulli, Vanessa Smith, Stefano Soldano
Format: Article
Language:English
Published: BioMed Central 2018-05-01
Series:Arthritis Research & Therapy
Subjects:
Prostacyclin receptor agonists
Skin fibroblasts
Fibrosis
Systemic sclerosis
Connective tissue diseases
Online Access:http://link.springer.com/article/10.1186/s13075-018-1577-0

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http://link.springer.com/article/10.1186/s13075-018-1577-0

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