Antiresorptive effect of a cathepsin K inhibitor ONO-5334 and its relationship to BMD increase in a phase II trial for postmenopausal osteoporosis

Antiresorptive effect of a cathepsin K inhibitor ONO-5334 and its relationship to BMD increase in a phase II trial for postmenopausal osteoporosis

Abstract Background ONO-5334 is a cathepsin K inhibitor that induced bone mineral density (BMD) gain in a phase II study in postmenopausal osteoporosis patients. Even though the antiresorptive effect could only be monitored in the morning during the study, simulation can allow the antiresorptive eff...

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Bibliographic Details
Main Authors: Makoto Tanaka, Yoshitaka Hashimoto, Chihiro Hasegawa, Steve Deacon, Richard Eastell
Format: Article
Language:English
Published: BioMed Central 2017-06-01
Series:BMC Musculoskeletal Disorders
Subjects:
Cathepsin K
ONO-5334
Bone resorption
PK/PD relationship
OCEAN study
Online Access:http://link.springer.com/article/10.1186/s12891-017-1625-y

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http://link.springer.com/article/10.1186/s12891-017-1625-y

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