Taxifolin inhibits amyloid-β oligomer formation and fully restores vascular integrity and memory in cerebral amyloid angiopathy

Taxifolin inhibits amyloid-β oligomer formation and fully restores vascular integrity and memory in cerebral amyloid angiopathy

Abstract Cerebral amyloid angiopathy (CAA) induces various forms of cerebral infarcts and hemorrhages from vascular amyloid-β accumulation, resulting in acceleration of cognitive impairment, which is currently untreatable. Soluble amyloid-β protein likely impairs cerebrovascular integrity as well as...

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Bibliographic Details
Main Authors: Satoshi Saito, Yumi Yamamoto, Takakuni Maki, Yorito Hattori, Hideki Ito, Katsuhiko Mizuno, Mariko Harada-Shiba, Raj N. Kalaria, Masanori Fukushima, Ryosuke Takahashi, Masafumi Ihara
Format: Article
Language:English
Published: BioMed Central 2017-04-01
Series:Acta Neuropathologica Communications
Subjects:
Alzheimer’s disease
Cerebral amyloid angiopathy
Oligomer
Taxifolin
Treatment
Online Access:http://link.springer.com/article/10.1186/s40478-017-0429-5

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http://link.springer.com/article/10.1186/s40478-017-0429-5

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