Increased circulating endothelial progenitor cells and improved short-term outcomes in acute non-cardioembolic stroke after hyperbaric oxygen therapy

Abstract Background Acute ischemic stroke is a leading cause of mortality and long-term disability, and profiles of endothelial progenitor cells (EPCs) reflect the degree of endothelial impairment. This study tested the hypothesis that hyperbaric oxygen therapy (HBOT) both improves the clinical shor...

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Main Authors:	Chen-Yu Chen, Re-Wen Wu, Nai-Wen Tsai, Mel S. Lee, Wei-Che Lin, Mei-Chi Hsu, Chih-Cheng Huang, Yun-Ru Lai, Chia-Te Kung, Hung-Chen Wang, Yu-Jih Su, Chih-Min Su, Sheng-Yuan Hsiao, Ben-Chung Cheng, Yi-Fang Chiang, Cheng-Hsien Lu
Format:	Article
Language:	English
Published:	BioMed Central 2018-09-01
Series:	Journal of Translational Medicine
Subjects:	Endothelial progenitor cells Hyperbaric oxygen therapy Non-cardioembolic stroke National Institutes of Health Stroke Scale Barthel index Modified Rankin Scale
Online Access:	http://link.springer.com/article/10.1186/s12967-018-1629-x

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spelling	doaj-art-be6099b9fd1147df8e1c374408be3c2e2018-09-16T11:14:18ZengBioMed CentralJournal of Translational Medicine1479-58762018-09-011611910.1186/s12967-018-1629-xIncreased circulating endothelial progenitor cells and improved short-term outcomes in acute non-cardioembolic stroke after hyperbaric oxygen therapyChen-Yu Chen0Re-Wen Wu1Nai-Wen Tsai2Mel S. Lee3Wei-Che Lin4Mei-Chi Hsu5Chih-Cheng Huang6Yun-Ru Lai7Chia-Te Kung8Hung-Chen Wang9Yu-Jih Su10Chih-Min Su11Sheng-Yuan Hsiao12Ben-Chung Cheng13Yi-Fang Chiang14Cheng-Hsien Lu15Department of Hyperbaric Oxygen Therapy Center, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of MedicineDepartment of Hyperbaric Oxygen Therapy Center, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of MedicineDepartment of Neurology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of MedicineDepartment of Hyperbaric Oxygen Therapy Center, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of MedicineDepartment of Radiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of MedicineDepartment of Nursing, I-Shou UniversityDepartment of Neurology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of MedicineDepartment of Neurology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of MedicineDepartment of Emergency Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of MedicineDepartment of Neurosurgery, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of MedicineDepartment of Rheumatology, Allergy and Immunology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of MedicineDepartment of Emergency Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of MedicineDepartment of Emergency Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of MedicineDepartment of Nephrology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of MedicineDepartment of Orthopaedic Surgery, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of MedicineDepartment of Neurology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of MedicineAbstract Background Acute ischemic stroke is a leading cause of mortality and long-term disability, and profiles of endothelial progenitor cells (EPCs) reflect the degree of endothelial impairment. This study tested the hypothesis that hyperbaric oxygen therapy (HBOT) both improves the clinical short-term outcomes and increases the number of circulating EPCs and antioxidant capacity. Methods The numbers of circulating EPCs [CD133+/CD34+ (%), KDR+/CD34+ (%)], biomarkers for oxidative stress (thiols and thiobarbituric acid-reactive substances), and clinical scores (National Institutes of Health Stroke Scale [NIHSS], Barthel index [BI], and modified Rankin Scale [MRS]) were prospectively evaluated in 25 patients with acute non-cardioembolic stroke under HBOT at two time points (pre- and post-HBOT). The biomarkers and clinical scores were compared with those of 25 age- and sex-matched disease controls. Results The numbers of KDR+/CD34+ (%) in the HBOT group following HBOT increased significantly, whereas the numbers of CD133+/CD34+ (%) also showed a tendency to increase without statistical significance. The mean high-sensitivity C-reactive protein levels showed significant decrease post-HBOT follow-up in the HBOT group. The changes in KDR+/CD34+EPC (%) numbers were positively correlated with changes in clinical outcomes scores (BI, NIHSS, and MRS) in the HBOT group. Conclusions Based on the results of our study, HBOT can both improve short-term clinical outcomes and increase the number of circulating EPCs in patients with acute non-cardioembolic stroke.http://link.springer.com/article/10.1186/s12967-018-1629-xEndothelial progenitor cellsHyperbaric oxygen therapyNon-cardioembolic strokeNational Institutes of Health Stroke ScaleBarthel indexModified Rankin Scale
institution	Open Data Bank
collection	Open Access Journals
building	Directory of Open Access Journals
language	English
format	Article
author	Chen-Yu Chen Re-Wen Wu Nai-Wen Tsai Mel S. Lee Wei-Che Lin Mei-Chi Hsu Chih-Cheng Huang Yun-Ru Lai Chia-Te Kung Hung-Chen Wang Yu-Jih Su Chih-Min Su Sheng-Yuan Hsiao Ben-Chung Cheng Yi-Fang Chiang Cheng-Hsien Lu
spellingShingle	Chen-Yu Chen Re-Wen Wu Nai-Wen Tsai Mel S. Lee Wei-Che Lin Mei-Chi Hsu Chih-Cheng Huang Yun-Ru Lai Chia-Te Kung Hung-Chen Wang Yu-Jih Su Chih-Min Su Sheng-Yuan Hsiao Ben-Chung Cheng Yi-Fang Chiang Cheng-Hsien Lu Increased circulating endothelial progenitor cells and improved short-term outcomes in acute non-cardioembolic stroke after hyperbaric oxygen therapy Journal of Translational Medicine Endothelial progenitor cells Hyperbaric oxygen therapy Non-cardioembolic stroke National Institutes of Health Stroke Scale Barthel index Modified Rankin Scale
author_facet	Chen-Yu Chen Re-Wen Wu Nai-Wen Tsai Mel S. Lee Wei-Che Lin Mei-Chi Hsu Chih-Cheng Huang Yun-Ru Lai Chia-Te Kung Hung-Chen Wang Yu-Jih Su Chih-Min Su Sheng-Yuan Hsiao Ben-Chung Cheng Yi-Fang Chiang Cheng-Hsien Lu
author_sort	Chen-Yu Chen
title	Increased circulating endothelial progenitor cells and improved short-term outcomes in acute non-cardioembolic stroke after hyperbaric oxygen therapy
title_short	Increased circulating endothelial progenitor cells and improved short-term outcomes in acute non-cardioembolic stroke after hyperbaric oxygen therapy
title_full	Increased circulating endothelial progenitor cells and improved short-term outcomes in acute non-cardioembolic stroke after hyperbaric oxygen therapy
title_fullStr	Increased circulating endothelial progenitor cells and improved short-term outcomes in acute non-cardioembolic stroke after hyperbaric oxygen therapy
title_full_unstemmed	Increased circulating endothelial progenitor cells and improved short-term outcomes in acute non-cardioembolic stroke after hyperbaric oxygen therapy
title_sort	increased circulating endothelial progenitor cells and improved short-term outcomes in acute non-cardioembolic stroke after hyperbaric oxygen therapy
publisher	BioMed Central
series	Journal of Translational Medicine
issn	1479-5876
publishDate	2018-09-01
description	Abstract Background Acute ischemic stroke is a leading cause of mortality and long-term disability, and profiles of endothelial progenitor cells (EPCs) reflect the degree of endothelial impairment. This study tested the hypothesis that hyperbaric oxygen therapy (HBOT) both improves the clinical short-term outcomes and increases the number of circulating EPCs and antioxidant capacity. Methods The numbers of circulating EPCs [CD133+/CD34+ (%), KDR+/CD34+ (%)], biomarkers for oxidative stress (thiols and thiobarbituric acid-reactive substances), and clinical scores (National Institutes of Health Stroke Scale [NIHSS], Barthel index [BI], and modified Rankin Scale [MRS]) were prospectively evaluated in 25 patients with acute non-cardioembolic stroke under HBOT at two time points (pre- and post-HBOT). The biomarkers and clinical scores were compared with those of 25 age- and sex-matched disease controls. Results The numbers of KDR+/CD34+ (%) in the HBOT group following HBOT increased significantly, whereas the numbers of CD133+/CD34+ (%) also showed a tendency to increase without statistical significance. The mean high-sensitivity C-reactive protein levels showed significant decrease post-HBOT follow-up in the HBOT group. The changes in KDR+/CD34+EPC (%) numbers were positively correlated with changes in clinical outcomes scores (BI, NIHSS, and MRS) in the HBOT group. Conclusions Based on the results of our study, HBOT can both improve short-term clinical outcomes and increase the number of circulating EPCs in patients with acute non-cardioembolic stroke.
topic	Endothelial progenitor cells Hyperbaric oxygen therapy Non-cardioembolic stroke National Institutes of Health Stroke Scale Barthel index Modified Rankin Scale
url	http://link.springer.com/article/10.1186/s12967-018-1629-x
_version_	1612573722759135232

Increased circulating endothelial progenitor cells and improved short-term outcomes in acute non-cardioembolic stroke after hyperbaric oxygen therapy

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