Identification of differential gene expression profile from peripheral blood cells of military pilots with hypertension by RNA sequencing analysis

Identification of differential gene expression profile from peripheral blood cells of military pilots with hypertension by RNA sequencing analysis

Abstract Background Elevated blood pressure is an important risk factor for cardiovascular disease and is also an important factor in global mortality. Military pilots are at high risk of cardiovascular disease because they undergo persistent noise, high mental tension, high altitude hypoxia, high a...

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Main Authors: Xing-Cheng Zhao, Shao-Hua Yang, Yi-Quan Yan, Xin Zhang, Lin Zhang, Bo Jiao, Shuai Jiang, Zhi-Bin Yu
Format: Article
Language:English
Published: BioMed Central 2018-07-01
Series:BMC Medical Genomics
Subjects:
Hypertension
Military pilots
Peripheral blood cells
RNA sequencing
Online Access:http://link.springer.com/article/10.1186/s12920-018-0378-2
id doaj-art-b4894bec5fdb44c7a5675b064311b86c
recordtype oai_dc
spelling doaj-art-b4894bec5fdb44c7a5675b064311b86c2018-08-15T22:26:31ZengBioMed CentralBMC Medical Genomics1755-87942018-07-0111111010.1186/s12920-018-0378-2Identification of differential gene expression profile from peripheral blood cells of military pilots with hypertension by RNA sequencing analysisXing-Cheng Zhao0Shao-Hua Yang1Yi-Quan Yan2Xin Zhang3Lin Zhang4Bo Jiao5Shuai Jiang6Zhi-Bin Yu7Department of Aerospace Physiology, Fourth Military Medical UniversityLintong Aviation Medical Evaluating and Training Center of Air ForceDepartment of Aerospace Physiology, Fourth Military Medical UniversityLintong Aviation Medical Evaluating and Training Center of Air ForceDepartment of Aerospace Physiology, Fourth Military Medical UniversityDepartment of Aerospace Physiology, Fourth Military Medical UniversityDepartment of Aerospace Physiology, Fourth Military Medical UniversityDepartment of Aerospace Physiology, Fourth Military Medical UniversityAbstract Background Elevated blood pressure is an important risk factor for cardiovascular disease and is also an important factor in global mortality. Military pilots are at high risk of cardiovascular disease because they undergo persistent noise, high mental tension, high altitude hypoxia, high acceleration and high calorie diet. Hypertension is the leading cause of cardiovascular disease in military pilots. In this study, we want to identify key genes from peripheral blood cells of military pilots with hypertension. Identification of these genes may help diagnose and control hypertension and extend flight career for military pilots. Methods We use RNA sequencing technology, bioinformatics analysis and Western blotting to identify key genes from peripheral blood cells of military pilots with hypertension. Results Our study detected 121 up-regulated genes and 623 down-regulated genes in the peripheral blood mononuclear cells (PBMCs) from hypertensive military pilots. We have also identified 8 important genes (NME4, PNPLA7, GGT5, PTGS2, IGF1R, NT5C2, ENTPD1 and PTEN), a number of gene ontology categories and biological pathways that may be associated with military pilot hypertension. Conclusions Our study may provide effective means for the prevention, diagnosis and treatment of hypertension for military pilot and extend their flight career.http://link.springer.com/article/10.1186/s12920-018-0378-2HypertensionMilitary pilotsPeripheral blood cellsRNA sequencing
institution Open Data Bank
collection Open Access Journals
building Directory of Open Access Journals
language English
format Article
author Xing-Cheng Zhao
Shao-Hua Yang
Yi-Quan Yan
Xin Zhang
Lin Zhang
Bo Jiao
Shuai Jiang
Zhi-Bin Yu
spellingShingle Xing-Cheng Zhao
Shao-Hua Yang
Yi-Quan Yan
Xin Zhang
Lin Zhang
Bo Jiao
Shuai Jiang
Zhi-Bin Yu
Identification of differential gene expression profile from peripheral blood cells of military pilots with hypertension by RNA sequencing analysis
BMC Medical Genomics
Hypertension
Military pilots
Peripheral blood cells
RNA sequencing
author_facet Xing-Cheng Zhao
Shao-Hua Yang
Yi-Quan Yan
Xin Zhang
Lin Zhang
Bo Jiao
Shuai Jiang
Zhi-Bin Yu
author_sort Xing-Cheng Zhao
title Identification of differential gene expression profile from peripheral blood cells of military pilots with hypertension by RNA sequencing analysis
title_short Identification of differential gene expression profile from peripheral blood cells of military pilots with hypertension by RNA sequencing analysis
title_full Identification of differential gene expression profile from peripheral blood cells of military pilots with hypertension by RNA sequencing analysis
title_fullStr Identification of differential gene expression profile from peripheral blood cells of military pilots with hypertension by RNA sequencing analysis
title_full_unstemmed Identification of differential gene expression profile from peripheral blood cells of military pilots with hypertension by RNA sequencing analysis
title_sort identification of differential gene expression profile from peripheral blood cells of military pilots with hypertension by rna sequencing analysis
publisher BioMed Central
series BMC Medical Genomics
issn 1755-8794
publishDate 2018-07-01
description Abstract Background Elevated blood pressure is an important risk factor for cardiovascular disease and is also an important factor in global mortality. Military pilots are at high risk of cardiovascular disease because they undergo persistent noise, high mental tension, high altitude hypoxia, high acceleration and high calorie diet. Hypertension is the leading cause of cardiovascular disease in military pilots. In this study, we want to identify key genes from peripheral blood cells of military pilots with hypertension. Identification of these genes may help diagnose and control hypertension and extend flight career for military pilots. Methods We use RNA sequencing technology, bioinformatics analysis and Western blotting to identify key genes from peripheral blood cells of military pilots with hypertension. Results Our study detected 121 up-regulated genes and 623 down-regulated genes in the peripheral blood mononuclear cells (PBMCs) from hypertensive military pilots. We have also identified 8 important genes (NME4, PNPLA7, GGT5, PTGS2, IGF1R, NT5C2, ENTPD1 and PTEN), a number of gene ontology categories and biological pathways that may be associated with military pilot hypertension. Conclusions Our study may provide effective means for the prevention, diagnosis and treatment of hypertension for military pilot and extend their flight career.
topic Hypertension
Military pilots
Peripheral blood cells
RNA sequencing
url http://link.springer.com/article/10.1186/s12920-018-0378-2
_version_ 1612703646941708288

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