Pin1 inhibition exerts potent activity against acute myeloid leukemia through blocking multiple cancer-driving pathways

Pin1 inhibition exerts potent activity against acute myeloid leukemia through blocking multiple cancer-driving pathways

Abstract Background The increasing genomic complexity of acute myeloid leukemia (AML), the most common form of acute leukemia, poses a major challenge to its therapy. To identify potent therapeutic targets with the ability to block multiple cancer-driving pathways is thus imperative. The unique pept...

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Bibliographic Details
Main Authors: Xiaolan Lian, Yu-Min Lin, Shingo Kozono, Megan K. Herbert, Xin Li, Xiaohong Yuan, Jiangrui Guo, Yafei Guo, Min Tang, Jia Lin, Yiping Huang, Bixin Wang, Chenxi Qiu, Cheng-Yu Tsai, Jane Xie, Ziang Jeff Gao, Yong Wu, Hekun Liu, Xiao Zhen Zhou, Kun Ping Lu, Yuanzhong Chen
Format: Article
Language:English
Published: BioMed Central 2018-05-01
Series:Journal of Hematology & Oncology
Subjects:
Acute myeloid leukemia (AML)
Pin1 inhibitor
All-trans retinoic acid (ATRA)
Oncogenic signaling
Leukemia treatment
Online Access:http://link.springer.com/article/10.1186/s13045-018-0611-7

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http://link.springer.com/article/10.1186/s13045-018-0611-7

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