4-1BB Signaling Promotes Alveolar Macrophages-Mediated Pro-Fibrotic Responses and Crystalline Silica-Induced Pulmonary Fibrosis in Mice

4-1BB Signaling Promotes Alveolar Macrophages-Mediated Pro-Fibrotic Responses and Crystalline Silica-Induced Pulmonary Fibrosis in Mice

Silicosis is caused by exposure to crystalline silica (CS). We have previously shown that blocking 4-1BB signaling attenuated CS-induced inflammation and pulmonary fibrosis. However, the cells that express 4-1BB, which plays a vital role in promoting fibrosis, are still unknown. In this study, we de...

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Bibliographic Details
Main Authors: Yiping Lu, Chao Li, Sitong Du, Xi Chen, Xinning Zeng, Fangwei Liu, Ying Chen, Jie Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Immunology
Subjects:
4-1BB
alveolar macrophages
crystalline silica
pro-fibrotic response
pulmonary fibrosis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01848/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01848/full

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