Food allergy in a child with de novo KAT6A mutation
Abstract Crying combined with miscellaneous gastrointestinal symptoms are typical symptoms of infant with food allergy, but are also common among children with abnormal neurological development. Mutations in KAT6A gene is known to cause a syndrome characterized by developmental delay, hypotonia, car...
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BioMed Central
2017-06-01
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| Series: | Clinical and Translational Allergy |
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| Online Access: | http://link.springer.com/article/10.1186/s13601-017-0155-x |
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doaj-art-add3d97abd5b47be94f4dfd14a81c3eb2018-08-16T01:13:37ZengBioMed CentralClinical and Translational Allergy2045-70222017-06-01711310.1186/s13601-017-0155-xFood allergy in a child with de novo KAT6A mutationVarpu Elenius0Tuire Lähdesmäki1Marja Hietala2Tuomas Jartti3Department of Pediatrics, Turku University HospitalDepartment of Pediatric Neurology, Turku University HospitalDepartment of Genetics, Turku University HospitalDepartment of Pediatrics, Turku University HospitalAbstract Crying combined with miscellaneous gastrointestinal symptoms are typical symptoms of infant with food allergy, but are also common among children with abnormal neurological development. Mutations in KAT6A gene is known to cause a syndrome characterized by developmental delay, hypotonia, cardiac defects, microcephaly, specific facial features and early feeding problems. However, these feeding problems have not earlier been specified. We present the first reported case of a DBPCFC confirmed food allergy in a child with KAT6A mutation whose feeding problems resolved with elimination diet. The present case does not establish proof of cause, but highlights the importance of careful clinical diagnostics despite other possible causes for feeding problems. Recognizing that early feeding problems these patients regularly have might be caused by food allergy is important for outcome and quality of life for these patients.http://link.springer.com/article/10.1186/s13601-017-0155-xFeeding problemsFood allergyHistone acetylationKAT6A mutation |
| institution |
Open Data Bank |
| collection |
Open Access Journals |
| building |
Directory of Open Access Journals |
| language |
English |
| format |
Article |
| author |
Varpu Elenius Tuire Lähdesmäki Marja Hietala Tuomas Jartti |
| spellingShingle |
Varpu Elenius Tuire Lähdesmäki Marja Hietala Tuomas Jartti Food allergy in a child with de novo KAT6A mutation Clinical and Translational Allergy Feeding problems Food allergy Histone acetylation KAT6A mutation |
| author_facet |
Varpu Elenius Tuire Lähdesmäki Marja Hietala Tuomas Jartti |
| author_sort |
Varpu Elenius |
| title |
Food allergy in a child with de novo KAT6A mutation |
| title_short |
Food allergy in a child with de novo KAT6A mutation |
| title_full |
Food allergy in a child with de novo KAT6A mutation |
| title_fullStr |
Food allergy in a child with de novo KAT6A mutation |
| title_full_unstemmed |
Food allergy in a child with de novo KAT6A mutation |
| title_sort |
food allergy in a child with de novo kat6a mutation |
| publisher |
BioMed Central |
| series |
Clinical and Translational Allergy |
| issn |
2045-7022 |
| publishDate |
2017-06-01 |
| description |
Abstract Crying combined with miscellaneous gastrointestinal symptoms are typical symptoms of infant with food allergy, but are also common among children with abnormal neurological development. Mutations in KAT6A gene is known to cause a syndrome characterized by developmental delay, hypotonia, cardiac defects, microcephaly, specific facial features and early feeding problems. However, these feeding problems have not earlier been specified. We present the first reported case of a DBPCFC confirmed food allergy in a child with KAT6A mutation whose feeding problems resolved with elimination diet. The present case does not establish proof of cause, but highlights the importance of careful clinical diagnostics despite other possible causes for feeding problems. Recognizing that early feeding problems these patients regularly have might be caused by food allergy is important for outcome and quality of life for these patients. |
| topic |
Feeding problems Food allergy Histone acetylation KAT6A mutation |
| url |
http://link.springer.com/article/10.1186/s13601-017-0155-x |
| _version_ |
1612695364383539200 |