Expression of von Hippel–Lindau tumor suppressor protein (pVHL) characteristic of tongue cancer and proliferative lesions in tongue epithelium

Expression of von Hippel–Lindau tumor suppressor protein (pVHL) characteristic of tongue cancer and proliferative lesions in tongue epithelium

Abstract Background Patients with tongue cancer frequently show loss of heterozygosity (LOH) of the von Hippel–Lindau (VHL) tumor suppressor gene. However, expression of VHL protein (pVHL) in tongue cancer has rarely been investigated and remains largely unknown. We performed immunohistochemical sta...

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Bibliographic Details
Main Authors: Hisashi Hasegawa, Yoshiaki Kusumi, Takeshi Asakawa, Miyoko Maeda, Toshinori Oinuma, Tohru Furusaka, Takeshi Oshima, Mariko Esumi
Format: Article
Language:English
Published: BioMed Central 2017-05-01
Series:BMC Cancer
Subjects:
Tongue cancer
pVHL
Diagnostic marker
Cytokeratin 13
Cytokeratin 17
Dysplasia
Online Access:http://link.springer.com/article/10.1186/s12885-017-3364-8

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http://link.springer.com/article/10.1186/s12885-017-3364-8

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