Transcriptional profiling of HERV-K(HML-2) in amyotrophic lateral sclerosis and potential implications for expression of HML-2 proteins

Transcriptional profiling of HERV-K(HML-2) in amyotrophic lateral sclerosis and potential implications for expression of HML-2 proteins

Abstract Background Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder. About 90% of ALS cases are without a known genetic cause. The human endogenous retrovirus multi-copy HERV-K(HML-2) group was recently reported to potentially contribute to neurodegeneration and disease pat...

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Bibliographic Details
Main Authors: Jens Mayer, Christian Harz, Laura Sanchez, Gavin C. Pereira, Esther Maldener, Sara R. Heras, Lyle W. Ostrow, John Ravits, Ranjan Batra, Eckart Meese, Jose Luis García-Pérez, John L. Goodier
Format: Article
Language:English
Published: BioMed Central 2018-08-01
Series:Molecular Neurodegeneration
Subjects:
Amyotrophic lateral sclerosis
Human endogenous retrovirus
HERV-K(HML-2)
Retrotransposon
Reverse transcription
Provirus
Online Access:http://link.springer.com/article/10.1186/s13024-018-0275-3

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