Electrochemotherapy efficacy evaluation for treatment of locally advanced stage III cutaneous squamous cell carcinoma: a 22-cases retrospective analysis

Abstract Background Extensive squamous cell carcinoma has few therapeutic options. In such cases, electrochemotherapy involving electroporation combined with antineoplastic drug appears to be a new potential option and may be considered as an alternative treatment. The aim of this retrospective sing...

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Main Authors:	Gianluca Di Monta, Corrado Caracò, Ester Simeone, Antonio Maria Grimaldi, Ugo Marone, Massimiliano Di Marzo, Vito Vanella, Lucia Festino, Marco Palla, Stefano Mori, Nicola Mozzillo, Paolo Antonio Ascierto
Format:	Article
Language:	English
Published:	BioMed Central 2017-04-01
Series:	Journal of Translational Medicine
Subjects:	Electrochemotherapy Electroporation Squamous cell carcinoma
Online Access:	http://link.springer.com/article/10.1186/s12967-017-1186-8

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spelling	doaj-art-9ff8a8c7d1064e2aa2939a43dde420f52018-08-15T22:58:59ZengBioMed CentralJournal of Translational Medicine1479-58762017-04-011511810.1186/s12967-017-1186-8Electrochemotherapy efficacy evaluation for treatment of locally advanced stage III cutaneous squamous cell carcinoma: a 22-cases retrospective analysisGianluca Di Monta0Corrado Caracò1Ester Simeone2Antonio Maria Grimaldi3Ugo Marone4Massimiliano Di Marzo5Vito Vanella6Lucia Festino7Marco Palla8Stefano Mori9Nicola Mozzillo10Paolo Antonio Ascierto11Department of Surgery “Melanoma-Soft Tissues-Head & Neck-Skin Cancers”, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione G. Pascale”Department of Surgery “Melanoma-Soft Tissues-Head & Neck-Skin Cancers”, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione G. Pascale”Unit of Medical Oncology and Innovative Therapy, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione G. Pascale”Unit of Medical Oncology and Innovative Therapy, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione G. Pascale”Department of Surgery “Melanoma-Soft Tissues-Head & Neck-Skin Cancers”, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione G. Pascale”Department of Surgery “Melanoma-Soft Tissues-Head & Neck-Skin Cancers”, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione G. Pascale”Unit of Medical Oncology and Innovative Therapy, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione G. Pascale”Unit of Medical Oncology and Innovative Therapy, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione G. Pascale”Unit of Medical Oncology and Innovative Therapy, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione G. Pascale”Department of Surgery “Melanoma-Soft Tissues-Head & Neck-Skin Cancers”, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione G. Pascale”Department of Surgery “Melanoma-Soft Tissues-Head & Neck-Skin Cancers”, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione G. Pascale”Unit of Medical Oncology and Innovative Therapy, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione G. Pascale”Abstract Background Extensive squamous cell carcinoma has few therapeutic options. In such cases, electrochemotherapy involving electroporation combined with antineoplastic drug appears to be a new potential option and may be considered as an alternative treatment. The aim of this retrospective single-center study was to evaluate electrochemotherapy efficacy in treatment of locally advanced stage III squamous cell carcinoma, in which surgical procedures would have entailed wide tissue sacrifice. Methods Clinical features, treatment response, and adverse effects were evaluated in 22 patients treated with electrochemotherapy with intravenous injection of bleomycin for extensive stage III cutaneous squamous cell carcinoma. Treatment of cutaneous lesions were performed according to the European Standard Operating Procedures of Electrochemotherapy. Results Overall response to electrochemotherapy treatment was observed in 18 (81.8%) patients. Clinical response with necrosis of tumor mass was observed from the first session and lasted for all follow up period that ranged between 5 and 48 months with a median of 34 months. Overall the treatment was well tolerated with a very low complication rate. Conclusions Electrochemotherapy represents a safe and effective therapeutic approach, associated with a good tolerability.http://link.springer.com/article/10.1186/s12967-017-1186-8ElectrochemotherapyElectroporationSquamous cell carcinoma
institution	Open Data Bank
collection	Open Access Journals
building	Directory of Open Access Journals
language	English
format	Article
author	Gianluca Di Monta Corrado Caracò Ester Simeone Antonio Maria Grimaldi Ugo Marone Massimiliano Di Marzo Vito Vanella Lucia Festino Marco Palla Stefano Mori Nicola Mozzillo Paolo Antonio Ascierto
spellingShingle	Gianluca Di Monta Corrado Caracò Ester Simeone Antonio Maria Grimaldi Ugo Marone Massimiliano Di Marzo Vito Vanella Lucia Festino Marco Palla Stefano Mori Nicola Mozzillo Paolo Antonio Ascierto Electrochemotherapy efficacy evaluation for treatment of locally advanced stage III cutaneous squamous cell carcinoma: a 22-cases retrospective analysis Journal of Translational Medicine Electrochemotherapy Electroporation Squamous cell carcinoma
author_facet	Gianluca Di Monta Corrado Caracò Ester Simeone Antonio Maria Grimaldi Ugo Marone Massimiliano Di Marzo Vito Vanella Lucia Festino Marco Palla Stefano Mori Nicola Mozzillo Paolo Antonio Ascierto
author_sort	Gianluca Di Monta
title	Electrochemotherapy efficacy evaluation for treatment of locally advanced stage III cutaneous squamous cell carcinoma: a 22-cases retrospective analysis
title_short	Electrochemotherapy efficacy evaluation for treatment of locally advanced stage III cutaneous squamous cell carcinoma: a 22-cases retrospective analysis
title_full	Electrochemotherapy efficacy evaluation for treatment of locally advanced stage III cutaneous squamous cell carcinoma: a 22-cases retrospective analysis
title_fullStr	Electrochemotherapy efficacy evaluation for treatment of locally advanced stage III cutaneous squamous cell carcinoma: a 22-cases retrospective analysis
title_full_unstemmed	Electrochemotherapy efficacy evaluation for treatment of locally advanced stage III cutaneous squamous cell carcinoma: a 22-cases retrospective analysis
title_sort	electrochemotherapy efficacy evaluation for treatment of locally advanced stage iii cutaneous squamous cell carcinoma: a 22-cases retrospective analysis
publisher	BioMed Central
series	Journal of Translational Medicine
issn	1479-5876
publishDate	2017-04-01
description	Abstract Background Extensive squamous cell carcinoma has few therapeutic options. In such cases, electrochemotherapy involving electroporation combined with antineoplastic drug appears to be a new potential option and may be considered as an alternative treatment. The aim of this retrospective single-center study was to evaluate electrochemotherapy efficacy in treatment of locally advanced stage III squamous cell carcinoma, in which surgical procedures would have entailed wide tissue sacrifice. Methods Clinical features, treatment response, and adverse effects were evaluated in 22 patients treated with electrochemotherapy with intravenous injection of bleomycin for extensive stage III cutaneous squamous cell carcinoma. Treatment of cutaneous lesions were performed according to the European Standard Operating Procedures of Electrochemotherapy. Results Overall response to electrochemotherapy treatment was observed in 18 (81.8%) patients. Clinical response with necrosis of tumor mass was observed from the first session and lasted for all follow up period that ranged between 5 and 48 months with a median of 34 months. Overall the treatment was well tolerated with a very low complication rate. Conclusions Electrochemotherapy represents a safe and effective therapeutic approach, associated with a good tolerability.
topic	Electrochemotherapy Electroporation Squamous cell carcinoma
url	http://link.springer.com/article/10.1186/s12967-017-1186-8
_version_	1612702130012946432

Electrochemotherapy efficacy evaluation for treatment of locally advanced stage III cutaneous squamous cell carcinoma: a 22-cases retrospective analysis

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