The NF-κB Inhibitor, IMD-0354, Affects Immune Gene Expression, Bacterial Microbiota and Trypanosoma cruzi Infection in Rhodnius prolixus Midgut

The NF-κB Inhibitor, IMD-0354, Affects Immune Gene Expression, Bacterial Microbiota and Trypanosoma cruzi Infection in Rhodnius prolixus Midgut

Rhodnius prolixus is an insect vector of Trypanosoma cruzi, the causative agent of Chagas disease in Latin America. Nuclear factor-κB (NF-κB) transcription factors (TF) are conserved components of the innate immune system in several multicellular organisms including insects. The drug IMD-0354 [N-(3,...

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Bibliographic Details
Main Authors: Cecilia S. Vieira, Otacílio C. Moreira, Kate K. S. Batista, Norman A. Ratcliffe, Daniele P. Castro, Patrícia Azambuja
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Physiology
Subjects:
insect immune system
Rhodnius prolixus
antimicrobial peptides
Nf-κB transcription factor
Trypanosoma cruzi
microbiota
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.01189/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2018.01189/full

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