Quantitative peptidomics of endogenous peptides involved in TGF-β1-induced epithelial mesenchymal transition of renal epithelial cells

Abstract TGF-β1 is a key fibrotic factor mediating epithelial mesenchymal transition (EMT) of epithelial cells through various signaling pathways. However, roles of proteolytic cleavage and endogenous peptide dynamics in TGF-β1-induced EMT remain unknown. We therefore performed quantitative peptidom...

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Bibliographic Details
Main Authors: Rattiyaporn Kanlaya, Visith Thongboonkerd
Format: Article
Language:English
Published: Nature Publishing Group 2018-02-01
Series:Cell Death Discovery
Online Access:http://link.springer.com/article/10.1038/s41420-017-0001-x