Intermedin attenuates renal fibrosis by induction of heme oxygenase-1 in rats with unilateral ureteral obstruction

Intermedin attenuates renal fibrosis by induction of heme oxygenase-1 in rats with unilateral ureteral obstruction

Abstract Background Intermedin [IMD, adrenomedullin-2 (ADM-2)] attenuates renal fibrosis by inhibition of oxidative stress. However, the precise mechanisms remain unknown. Heme oxygenase-1 (HO-1), an antioxidant agent, is associated with antifibrogenic effects. ADM is known to induce HO-1. Whether I...

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Bibliographic Details
Main Authors: Xi Qiao, Lihua Wang, Yanhong Wang, Xiaole Su, Yufeng Qiao, Yun Fan, Zhiqiang Peng
Format: Article
Language:English
Published: BioMed Central 2017-07-01
Series:BMC Nephrology
Subjects:
Intermedin
Renal
Fibrosis
Reactive oxygen species
Heme oxygenase-1
Online Access:http://link.springer.com/article/10.1186/s12882-017-0659-6

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http://link.springer.com/article/10.1186/s12882-017-0659-6

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