Ecto-5′-nucleotidase (CD73) attenuates inflammation after spinal cord injury by promoting macrophages/microglia M2 polarization in mice

Ecto-5′-nucleotidase (CD73) attenuates inflammation after spinal cord injury by promoting macrophages/microglia M2 polarization in mice

Abstract Background Immune activation, specifically activation of macrophages and resident microglia, leading to inflammation is a key component in the progression of spinal cord injury (SCI). Macrophages/microglia exist in two states—the classically activated M1 phenotype that confers pro-inflammat...

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Bibliographic Details
Main Authors: Shun Xu, Wei Zhu, Minghao Shao, Fan Zhang, Ji Guo, Haocheng Xu, Jianyuan Jiang, Xiaosheng Ma, Xinlei Xia, Xiuling Zhi, Ping Zhou, Feizhou Lu
Format: Article
Language:English
Published: BioMed Central 2018-05-01
Series:Journal of Neuroinflammation
Subjects:
SCI
CD73
Microglial polarization
Adenosine A2B receptor
p38
Online Access:http://link.springer.com/article/10.1186/s12974-018-1183-8

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http://link.springer.com/article/10.1186/s12974-018-1183-8

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