Regulatory landscape fusion in rhabdomyosarcoma through interactions between the PAX3 promoter and FOXO1 regulatory elements

Regulatory landscape fusion in rhabdomyosarcoma through interactions between the PAX3 promoter and FOXO1 regulatory elements

Abstract Background The organisation of vertebrate genomes into topologically associating domains (TADs) is believed to facilitate the regulation of the genes located within them. A remaining question is whether TAD organisation is achieved through the interactions of the regulatory elements within...

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Main Authors: Cristina Vicente-García, Barbara Villarejo-Balcells, Ibai Irastorza-Azcárate, Silvia Naranjo, Rafael D. Acemel, Juan J. Tena, Peter W. J. Rigby, Damien P. Devos, Jose L. Gómez-Skarmeta, Jaime J. Carvajal
Format: Article
Language:English
Published: BioMed Central 2017-06-01
Series:Genome Biology
Subjects:
TAD
CTCF
Transcriptional regulation
FOXO1
PAX3
Alveolar rhabdomyosarcoma
Online Access:http://link.springer.com/article/10.1186/s13059-017-1225-z

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http://link.springer.com/article/10.1186/s13059-017-1225-z

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