CRISPR-SKIP: programmable gene splicing with single base editors

CRISPR-SKIP: programmable gene splicing with single base editors

Abstract CRISPR gene editing has revolutionized biomedicine and biotechnology by providing a simple means to engineer genes through targeted double-strand breaks in the genomic DNA of living cells. However, given the stochasticity of cellular DNA repair mechanisms and the potential for off-target mu...

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Bibliographic Details
Main Authors: Michael Gapinske, Alan Luu, Jackson Winter, Wendy S. Woods, Kurt A. Kostan, Nikhil Shiva, Jun S. Song, Pablo Perez-Pinera
Format: Article
Language:English
Published: BioMed Central 2018-08-01
Series:Genome Biology
Subjects:
Gene editing
Base editing
Exon skipping
Alternative splicing
Synthetic biology
CRISPR-Cas9
Online Access:http://link.springer.com/article/10.1186/s13059-018-1482-5

Internet

http://link.springer.com/article/10.1186/s13059-018-1482-5

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