MICMIC: identification of DNA methylation of distal regulatory regions with causal effects on tumorigenesis

MICMIC: identification of DNA methylation of distal regulatory regions with causal effects on tumorigenesis

Abstract Aberrant promoter methylation is a common mechanism for tumor suppressor inactivation in cancer. We develop a set of tools to identify genome-wide DNA methylation in distal regions with causal effect on tumorigenesis called MICMIC. Many predictions are directly validated by dCas9-based epig...

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Bibliographic Details
Main Authors: Yin Tong, Jianlong Sun, Chi Fat Wong, Qingzheng Kang, Beibei Ru, Ching Ngar Wong, April Sheila Chan, Suet Yi Leung, Jiangwen Zhang
Format: Article
Language:English
Published: BioMed Central 2018-06-01
Series:Genome Biology
Subjects:
DNA methylation
Enhancer
Bioinformatics
Cancer
Information theoretic approaches
Epigenetic editing
Online Access:http://link.springer.com/article/10.1186/s13059-018-1442-0

Internet

http://link.springer.com/article/10.1186/s13059-018-1442-0

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