EFFECTS OF LACTIC ACID BACTERIA PROBIOTIC ON URINARE OXALATE EXCRETION AND PREVENTION OF RECURRENT PYELONEPHRITIS

EFFECTS OF LACTIC ACID BACTERIA PROBIOTIC ON URINARE OXALATE EXCRETION AND PREVENTION OF RECURRENT PYELONEPHRITIS

The present study was performed to evaluate the ability of Lactobacillus probiotics to reduce the urinary oxalate excretion level and prevent recurrent pyelonephritis. Methods. The open, 6 months randomized controlled trial was followed up. 80 women with recurrent pyelonephritis, caused by E. col...

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Main Authors: N. Stepanova, N. Stashevska, L. Lebid, M. Kolesnyk
Format: Article
Language:English
Published: State Institution «Institute of Nephrology NAMS of Ukraine" 2017-10-01
Series:Український Журнал Нефрології та Діалізу
Subjects:
recurrent pyelonephritis, hyperoxaluria, lactic acid bacteria, treatment
Online Access:https://ukrjnd.com.ua/index.php/journal/article/view/50
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spelling doaj-art-877f5ad4b589437883170cddbb4f4d8f2018-09-03T10:43:01ZengState Institution «Institute of Nephrology NAMS of Ukraine" Український Журнал Нефрології та Діалізу2304-02382616-73522017-10-014(56)374110.31450/ukrjnd.4(56).2017.0350EFFECTS OF LACTIC ACID BACTERIA PROBIOTIC ON URINARE OXALATE EXCRETION AND PREVENTION OF RECURRENT PYELONEPHRITISN. Stepanova0N. Stashevska1L. Lebid2M. Kolesnyk3SI «Institute of Nephrology of the National Academy of Medical Sciences»SI «Institute of Nephrology of the National Academy of Medical Sciences»SI «Institute of Nephrology of the National Academy of Medical Sciences»SI «Institute of Nephrology of the National Academy of Medical Sciences»The present study was performed to evaluate the ability of Lactobacillus probiotics to reduce the urinary oxalate excretion level and prevent recurrent pyelonephritis. Methods. The open, 6 months randomized controlled trial was followed up. 80 women with recurrent pyelonephritis, caused by E. coli or S. faecalis, were randomly allocated into 2 groups. The 1st Group (n = 40) took Symbiform® which contained acidophilic and plantar Lactobacilli, Lactococci (lactis and cremoris), Bifidobacteria (adolescentis and bifidum) and thermophilic non–pathogenic Streptococcus. The 2nd one (n = 40) received oxalate–soluble herbal remedy Uronefron® containing 188 mg of city extract from 9 plants. Probiotic was prescribed in a dose of 1 sachet 2 times a day during the first 5 days, followed by a dose reduction of 1 sachet per day for a month. Uronefron® was prescribed in a dose of 3 pills a day for a month. Results. 1 month after the end of the treatment, microbiological studies of the colon microflora demonstrated the increasing level of Lactobacillus spp. colonization more than 7 million CPU/1 g of faeces: 35/40 (87.5 %) in the patients of the 1st Group vs 6/40 (15 %) in the women of the comparison Group f/f = 41.5; p < 0.0001). The levels of daily urinary oxalate excretion were significantly decreased in both groups: the patients of Probiotic Group: 117.6 ± 11.7 vs 71.9 ± 10.07mg/d after the treatment (p < 0.0001) and 122.02 ± 17 vs 84.8 ± 9.8 mg/d (p < 0.0001) in the women of the 2nd Group, respectively. In the 6 months preceding randomization, at least 1 recurrence of pyelonephritis occurred in 2/40 (5 %) women of the Probiotic Group and 9/40 (22.5 %) in the patients of Group II (//= 5,1; p = 0,02). Conclusions. The use of lactobacillus probiotics in non–stone fanners women with recurrent pyelonephritis increases the quantitative content of Lactobacillus spp. in the gut, reduces daily urinary oxalate excretion and the number of pyelonephritis recurrences.https://ukrjnd.com.ua/index.php/journal/article/view/50recurrent pyelonephritis, hyperoxaluria, lactic acid bacteria, treatment
institution Open Data Bank
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language English
format Article
author N. Stepanova
N. Stashevska
L. Lebid
M. Kolesnyk
spellingShingle N. Stepanova
N. Stashevska
L. Lebid
M. Kolesnyk
EFFECTS OF LACTIC ACID BACTERIA PROBIOTIC ON URINARE OXALATE EXCRETION AND PREVENTION OF RECURRENT PYELONEPHRITIS
Український Журнал Нефрології та Діалізу
recurrent pyelonephritis, hyperoxaluria, lactic acid bacteria, treatment
author_facet N. Stepanova
N. Stashevska
L. Lebid
M. Kolesnyk
author_sort N. Stepanova
title EFFECTS OF LACTIC ACID BACTERIA PROBIOTIC ON URINARE OXALATE EXCRETION AND PREVENTION OF RECURRENT PYELONEPHRITIS
title_short EFFECTS OF LACTIC ACID BACTERIA PROBIOTIC ON URINARE OXALATE EXCRETION AND PREVENTION OF RECURRENT PYELONEPHRITIS
title_full EFFECTS OF LACTIC ACID BACTERIA PROBIOTIC ON URINARE OXALATE EXCRETION AND PREVENTION OF RECURRENT PYELONEPHRITIS
title_fullStr EFFECTS OF LACTIC ACID BACTERIA PROBIOTIC ON URINARE OXALATE EXCRETION AND PREVENTION OF RECURRENT PYELONEPHRITIS
title_full_unstemmed EFFECTS OF LACTIC ACID BACTERIA PROBIOTIC ON URINARE OXALATE EXCRETION AND PREVENTION OF RECURRENT PYELONEPHRITIS
title_sort effects of lactic acid bacteria probiotic on urinare oxalate excretion and prevention of recurrent pyelonephritis
publisher State Institution «Institute of Nephrology NAMS of Ukraine"
series Український Журнал Нефрології та Діалізу
issn 2304-0238
2616-7352
publishDate 2017-10-01
description The present study was performed to evaluate the ability of Lactobacillus probiotics to reduce the urinary oxalate excretion level and prevent recurrent pyelonephritis. Methods. The open, 6 months randomized controlled trial was followed up. 80 women with recurrent pyelonephritis, caused by E. coli or S. faecalis, were randomly allocated into 2 groups. The 1st Group (n = 40) took Symbiform® which contained acidophilic and plantar Lactobacilli, Lactococci (lactis and cremoris), Bifidobacteria (adolescentis and bifidum) and thermophilic non–pathogenic Streptococcus. The 2nd one (n = 40) received oxalate–soluble herbal remedy Uronefron® containing 188 mg of city extract from 9 plants. Probiotic was prescribed in a dose of 1 sachet 2 times a day during the first 5 days, followed by a dose reduction of 1 sachet per day for a month. Uronefron® was prescribed in a dose of 3 pills a day for a month. Results. 1 month after the end of the treatment, microbiological studies of the colon microflora demonstrated the increasing level of Lactobacillus spp. colonization more than 7 million CPU/1 g of faeces: 35/40 (87.5 %) in the patients of the 1st Group vs 6/40 (15 %) in the women of the comparison Group f/f = 41.5; p < 0.0001). The levels of daily urinary oxalate excretion were significantly decreased in both groups: the patients of Probiotic Group: 117.6 ± 11.7 vs 71.9 ± 10.07mg/d after the treatment (p < 0.0001) and 122.02 ± 17 vs 84.8 ± 9.8 mg/d (p < 0.0001) in the women of the 2nd Group, respectively. In the 6 months preceding randomization, at least 1 recurrence of pyelonephritis occurred in 2/40 (5 %) women of the Probiotic Group and 9/40 (22.5 %) in the patients of Group II (//= 5,1; p = 0,02). Conclusions. The use of lactobacillus probiotics in non–stone fanners women with recurrent pyelonephritis increases the quantitative content of Lactobacillus spp. in the gut, reduces daily urinary oxalate excretion and the number of pyelonephritis recurrences.
topic recurrent pyelonephritis, hyperoxaluria, lactic acid bacteria, treatment
url https://ukrjnd.com.ua/index.php/journal/article/view/50
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