Ang II-AT2R increases mesenchymal stem cell migration by signaling through the FAK and RhoA/Cdc42 pathways in vitro

Ang II-AT2R increases mesenchymal stem cell migration by signaling through the FAK and RhoA/Cdc42 pathways in vitro

Abstract Background Mesenchymal stem cells (MSCs) migrate via the bloodstream to sites of injury and are possibly attracted by inflammatory factors. As a proinflammatory mediator, angiotensin II (Ang II) reportedly enhances the migration of various cell types by signaling via the Ang II receptor in...

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Bibliographic Details
Main Authors: Xiu-ping Xu, Hong-li He, Shu-ling Hu, Ji-bin Han, Li-li Huang, Jing-yuan Xu, Jian-feng Xie, Ai-ran Liu, Yi Yang, Hai-bo Qiu
Format: Article
Language:English
Published: BioMed Central 2017-07-01
Series:Stem Cell Research & Therapy
Subjects:
Mesenchymal stem cells
Angiotensin II
AT1R
AT2R
Cell migration
Focal adhesion kinase
Online Access:http://link.springer.com/article/10.1186/s13287-017-0617-z

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http://link.springer.com/article/10.1186/s13287-017-0617-z

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