Expression and function of osteopontin in vascular adventitial fibroblasts and pathological vascular remodeling.

Osteopontin is known to play important roles in various diseases including vascular disorders. However, little is known about its expression and function in vascular adventitial fibroblasts. Adventitial fibroblasts have been shown to play a key role in pathological vascular remodeling associating wi...

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Main Authors:	Xin Jin, Guo-xiang Fu, Xiao-dong Li, Ding-liang Zhu, Ping-jin Gao
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS)
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC3176202?pdf=render

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spelling	doaj-art-7fcbc4dfe5184f96a03474b9ae7f73002018-08-23T04:49:27ZengPublic Library of Science (PLoS)PLoS ONE1932-620369e2355810.1371/journal.pone.0023558Expression and function of osteopontin in vascular adventitial fibroblasts and pathological vascular remodeling.Xin JinGuo-xiang FuXiao-dong LiDing-liang ZhuPing-jin GaoOsteopontin is known to play important roles in various diseases including vascular disorders. However, little is known about its expression and function in vascular adventitial fibroblasts. Adventitial fibroblasts have been shown to play a key role in pathological vascular remodeling associating with various vascular disorders. In this study, we measured activation of Osteopontin and its biological functions in cultured adventitial fibroblasts and injured rat carotid injury arteries induced by balloon angioplasty. Our results showed that angiotensin II and aldosterone increased Osteopontin expression in adventitial fibroblasts in a time- and concentration-dependent manner. MAPKs and AP-1 pathways were involved in Osteopontin upregulation. In addition, Adventitial fibroblast migration stimulated by Angiotensin II and aldosterone required OPN expression. Perivascular delivery of antisense oligonucleotide for Osteopontin suppressed neointimal formation post-injury. We concluded that upregulation of Osteopontin expression in adventitial fibroblasts might be important in the pathogenesis of vascular remodeling after arterial injury.http://europepmc.org/articles/PMC3176202?pdf=render
institution	Open Data Bank
collection	Open Access Journals
building	Directory of Open Access Journals
language	English
format	Article
author	Xin Jin Guo-xiang Fu Xiao-dong Li Ding-liang Zhu Ping-jin Gao
spellingShingle	Xin Jin Guo-xiang Fu Xiao-dong Li Ding-liang Zhu Ping-jin Gao Expression and function of osteopontin in vascular adventitial fibroblasts and pathological vascular remodeling. PLoS ONE
author_facet	Xin Jin Guo-xiang Fu Xiao-dong Li Ding-liang Zhu Ping-jin Gao
author_sort	Xin Jin
title	Expression and function of osteopontin in vascular adventitial fibroblasts and pathological vascular remodeling.
title_short	Expression and function of osteopontin in vascular adventitial fibroblasts and pathological vascular remodeling.
title_full	Expression and function of osteopontin in vascular adventitial fibroblasts and pathological vascular remodeling.
title_fullStr	Expression and function of osteopontin in vascular adventitial fibroblasts and pathological vascular remodeling.
title_full_unstemmed	Expression and function of osteopontin in vascular adventitial fibroblasts and pathological vascular remodeling.
title_sort	expression and function of osteopontin in vascular adventitial fibroblasts and pathological vascular remodeling.
publisher	Public Library of Science (PLoS)
series	PLoS ONE
issn	1932-6203
description	Osteopontin is known to play important roles in various diseases including vascular disorders. However, little is known about its expression and function in vascular adventitial fibroblasts. Adventitial fibroblasts have been shown to play a key role in pathological vascular remodeling associating with various vascular disorders. In this study, we measured activation of Osteopontin and its biological functions in cultured adventitial fibroblasts and injured rat carotid injury arteries induced by balloon angioplasty. Our results showed that angiotensin II and aldosterone increased Osteopontin expression in adventitial fibroblasts in a time- and concentration-dependent manner. MAPKs and AP-1 pathways were involved in Osteopontin upregulation. In addition, Adventitial fibroblast migration stimulated by Angiotensin II and aldosterone required OPN expression. Perivascular delivery of antisense oligonucleotide for Osteopontin suppressed neointimal formation post-injury. We concluded that upregulation of Osteopontin expression in adventitial fibroblasts might be important in the pathogenesis of vascular remodeling after arterial injury.
url	http://europepmc.org/articles/PMC3176202?pdf=render
_version_	1612674960057171968

Expression and function of osteopontin in vascular adventitial fibroblasts and pathological vascular remodeling.

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