ABCA1 haplodeficiency affects the brain transcriptome following traumatic brain injury in mice expressing human APOE isoforms

ABCA1 haplodeficiency affects the brain transcriptome following traumatic brain injury in mice expressing human APOE isoforms

Abstract Expression of human Apolipoprotein E (APOE) modulates the inflammatory response in an isoform specific manner, with APOE4 isoform eliciting a stronger pro-inflammatory response, suggesting a possible mechanism for worse outcome following traumatic brain injury (TBI). APOE lipidation and sta...

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Bibliographic Details
Main Authors: Emilie L. Castranio, Cody M. Wolfe, Kyong Nyon Nam, Florent Letronne, Nicholas F. Fitz, Iliya Lefterov, Radosveta Koldamova
Format: Article
Language:English
Published: BioMed Central 2018-07-01
Series:Acta Neuropathologica Communications
Subjects:
Traumatic brain injury
Apolipoprotein E
ABCA1
Transcriptome
WGCNA
Microglia sensome
Online Access:http://link.springer.com/article/10.1186/s40478-018-0569-2

Internet

http://link.springer.com/article/10.1186/s40478-018-0569-2

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