Forward genetic screening for regulators involved in cholesterol synthesis using validation-based insertional mutagenesis.
Somatic cell genetics is a powerful approach for unraveling the regulatory mechanism of cholesterol metabolism. However, it is difficult to identify the mutant gene(s) due to cells are usually mutagenized chemically or physically. To identify important genes controlling cholesterol biosynthesis, an...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4245081?pdf=render |