Enhanced immunocompatibility of ligand-targeted liposomes by attenuating natural IgM absorption

Enhanced immunocompatibility of ligand-targeted liposomes by attenuating natural IgM absorption

Targeting ligands on drug carriers can trigger immune responses. Here, the authors modify liposomes with a peptidomimetic that preserves bioactivity of the nanocarrier in blood circulation and attenuates IgM absorption, thereby improving the immunocompatibility of brain-targeted liposomes.

Bibliographic Details
Main Authors: Juan Guan, Qing Shen, Zui Zhang, Zhuxuan Jiang, Yang Yang, Meiqing Lou, Jun Qian, Weiyue Lu, Changyou Zhan
Format: Article
Language:English
Published: Nature Publishing Group 2018-07-01
Series:Nature Communications
Online Access:http://link.springer.com/article/10.1038/s41467-018-05384-1

Internet

http://link.springer.com/article/10.1038/s41467-018-05384-1

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