Gout and subsequent erectile dysfunction: a population-based cohort study from England

Abstract Background An association has been suggested between gout and erectile dysfunction (ED), however studies quantifying the risk of ED amongst gout patients are lacking. We aimed to precisely determine the population-level absolute and relative rate of ED reporting among men with gout over a d...

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Main Authors:	Alyshah Abdul Sultan, Christian Mallen, Richard Hayward, Sara Muller, Rebecca Whittle, Matthew Hotston, Edward Roddy
Format:	Article
Language:	English
Published:	BioMed Central 2017-06-01
Series:	Arthritis Research & Therapy
Subjects:	Gout Erectile dysfunction Incidence rate Epidemiology
Online Access:	http://link.springer.com/article/10.1186/s13075-017-1322-0

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spelling	doaj-art-638423347d174b3fbd444ad994b160c82018-08-20T18:30:46ZengBioMed CentralArthritis Research & Therapy1478-63622017-06-011911810.1186/s13075-017-1322-0Gout and subsequent erectile dysfunction: a population-based cohort study from EnglandAlyshah Abdul Sultan0Christian Mallen1Richard Hayward2Sara Muller3Rebecca Whittle4Matthew Hotston5Edward Roddy6Arthritis Research UK Primary Care Centre, Research Institute for Primary Care & Health Sciences, Keele University, KeeleArthritis Research UK Primary Care Centre, Research Institute for Primary Care & Health Sciences, Keele University, KeeleArthritis Research UK Primary Care Centre, Research Institute for Primary Care & Health Sciences, Keele University, KeeleArthritis Research UK Primary Care Centre, Research Institute for Primary Care & Health Sciences, Keele University, KeeleArthritis Research UK Primary Care Centre, Research Institute for Primary Care & Health Sciences, Keele University, KeeleRoyal Cornwall HospitalArthritis Research UK Primary Care Centre, Research Institute for Primary Care & Health Sciences, Keele University, KeeleAbstract Background An association has been suggested between gout and erectile dysfunction (ED), however studies quantifying the risk of ED amongst gout patients are lacking. We aimed to precisely determine the population-level absolute and relative rate of ED reporting among men with gout over a decade in England. Methods We utilised the UK-based Clinical Practice Research Datalink to identify 9653 men with incident gout age- and practice-matched to 38,218 controls. Absolute and relative rates of incident ED were calculated using Cox regression models. Absolute rates within specific time periods before and after gout diagnosis were compared to control using a Poisson regression model. Results Overall, the absolute rate of ED post-gout diagnosis was 193 (95% confidence interval (CI): 184–202) per 10,000 person-years. This corresponded to a 31% (hazard ratio (HR): 1.31 95%CI: 1.24–1.40) increased relative risk and 0.6% excess absolute risk compared to those without gout. We did not observe statistically significant differences in the risk of ED among those prescribed ULT within 1 and 3 years after gout diagnosis. Compared to those unexposed, the risk of ED was also high in the year before gout diagnosis (relative rate = 1.63 95%CI 1.27–2.08). Similar findings were also observed for severe ED warranting pharmacological intervention. Conclusions We have shown a statistically significant increased risk of ED among men with gout. Our findings will have important implications in planning a multidisciplinary approach to managing patients with gout.http://link.springer.com/article/10.1186/s13075-017-1322-0GoutErectile dysfunctionIncidence rateEpidemiology
institution	Open Data Bank
collection	Open Access Journals
building	Directory of Open Access Journals
language	English
format	Article
author	Alyshah Abdul Sultan Christian Mallen Richard Hayward Sara Muller Rebecca Whittle Matthew Hotston Edward Roddy
spellingShingle	Alyshah Abdul Sultan Christian Mallen Richard Hayward Sara Muller Rebecca Whittle Matthew Hotston Edward Roddy Gout and subsequent erectile dysfunction: a population-based cohort study from England Arthritis Research & Therapy Gout Erectile dysfunction Incidence rate Epidemiology
author_facet	Alyshah Abdul Sultan Christian Mallen Richard Hayward Sara Muller Rebecca Whittle Matthew Hotston Edward Roddy
author_sort	Alyshah Abdul Sultan
title	Gout and subsequent erectile dysfunction: a population-based cohort study from England
title_short	Gout and subsequent erectile dysfunction: a population-based cohort study from England
title_full	Gout and subsequent erectile dysfunction: a population-based cohort study from England
title_fullStr	Gout and subsequent erectile dysfunction: a population-based cohort study from England
title_full_unstemmed	Gout and subsequent erectile dysfunction: a population-based cohort study from England
title_sort	gout and subsequent erectile dysfunction: a population-based cohort study from england
publisher	BioMed Central
series	Arthritis Research & Therapy
issn	1478-6362
publishDate	2017-06-01
description	Abstract Background An association has been suggested between gout and erectile dysfunction (ED), however studies quantifying the risk of ED amongst gout patients are lacking. We aimed to precisely determine the population-level absolute and relative rate of ED reporting among men with gout over a decade in England. Methods We utilised the UK-based Clinical Practice Research Datalink to identify 9653 men with incident gout age- and practice-matched to 38,218 controls. Absolute and relative rates of incident ED were calculated using Cox regression models. Absolute rates within specific time periods before and after gout diagnosis were compared to control using a Poisson regression model. Results Overall, the absolute rate of ED post-gout diagnosis was 193 (95% confidence interval (CI): 184–202) per 10,000 person-years. This corresponded to a 31% (hazard ratio (HR): 1.31 95%CI: 1.24–1.40) increased relative risk and 0.6% excess absolute risk compared to those without gout. We did not observe statistically significant differences in the risk of ED among those prescribed ULT within 1 and 3 years after gout diagnosis. Compared to those unexposed, the risk of ED was also high in the year before gout diagnosis (relative rate = 1.63 95%CI 1.27–2.08). Similar findings were also observed for severe ED warranting pharmacological intervention. Conclusions We have shown a statistically significant increased risk of ED among men with gout. Our findings will have important implications in planning a multidisciplinary approach to managing patients with gout.
topic	Gout Erectile dysfunction Incidence rate Epidemiology
url	http://link.springer.com/article/10.1186/s13075-017-1322-0
_version_	1612683711015288832

Gout and subsequent erectile dysfunction: a population-based cohort study from England

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