eIF2α phosphorylation is required to prevent hepatocyte death and liver fibrosis in mice challenged with a high fructose diet

eIF2α phosphorylation is required to prevent hepatocyte death and liver fibrosis in mice challenged with a high fructose diet

Abstract Background Dietary fructose can rapidly cause fatty liver in animals through de novo lipogenesis (DNL) and contribute to the development and severity of nonalcoholic fatty liver disease (NAFLD). In response to diverse cellular insults including endoplasmic reticulum (ER) and oxidative stres...

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Bibliographic Details
Main Authors: Woo-Gyun Choi, Jaeseok Han, Ji-Hyeon Kim, Mi-Jeong Kim, Jae-Woo Park, Benbo Song, Hee-Jeong Cha, Hye-Seon Choi, Hun-Taeg Chung, In-Kyu Lee, Tae-Sik Park, Maria Hatzoglou, Hueng-Sik Choi, Hyun Ju Yoo, Randal J. Kaufman, Sung Hoon Back
Format: Article
Language:English
Published: BioMed Central 2017-08-01
Series:Nutrition & Metabolism
Subjects:
Nonalcoholic fatty liver disease
Fibrosis
High fructose diet
eIF2α phosphorylation
Aging
Oxidative stress
Online Access:http://link.springer.com/article/10.1186/s12986-017-0202-6

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