A natural chalcone induces apoptosis in lung cancer cells: 3D-QSAR, docking and an in vivo/vitro assay

Abstract This study was to study the antitumor effect of lonchocarpin (34) from traditional herbal medicine Pongamia pinnata (L.) Pierre and to reveal the underlying mechanism. The cytotoxic activities of lonchocarpin were evaluated in 10 lung cancer cell lines and it exhibited 97.5% activity at a d...

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Bibliographic Details
Main Authors: Gang Chen, Di Zhou, Xue-Zheng Li, Zhe Jiang, Chengyu Tan, Xiu-Yan Wei, Junhong Ling, Jing Jing, Fen Liu, Ning Li
Format: Article
Language:English
Published: Nature Publishing Group 2017-09-01
Series:Scientific Reports
Online Access:http://link.springer.com/article/10.1038/s41598-017-11369-9