Suppression of Slit3 induces tumor proliferation and chemoresistance in hepatocellular carcinoma through activation of GSK3β/β-catenin pathway

Suppression of Slit3 induces tumor proliferation and chemoresistance in hepatocellular carcinoma through activation of GSK3β/β-catenin pathway

Abstract Background It is essential to understand the mechanisms responsible for hepatocellular carcinoma (HCC) progression and chemoresistance in order to identify prognostic biomarkers as well as potential therapeutic avenues. Recent findings have shown that SLIT3 appears to function as a novel tu...

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Bibliographic Details
Main Authors: Lui Ng, Ariel K. M. Chow, Johnny H. W. Man, Thomas C. C. Yau, Timothy M. H. Wan, Deepak N. Iyer, Virginia H. T. Kwan, Ronnie T. P. Poon, Roberta W. C. Pang, Wai-Lun Law
Format: Article
Language:English
Published: BioMed Central 2018-06-01
Series:BMC Cancer
Subjects:
Slit3
β-catenin
GSK3β
Chemoresistanc
Sorafenib
Oxaliplatin
Online Access:http://link.springer.com/article/10.1186/s12885-018-4326-5

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http://link.springer.com/article/10.1186/s12885-018-4326-5

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