GABAB Receptors Augment TRPC3-Mediated Slow Excitatory Postsynaptic Current to Regulate Cerebellar Purkinje Neuron Response to Type-1 Metabotropic Glutamate Receptor Activation

GABAB Receptors Augment TRPC3-Mediated Slow Excitatory Postsynaptic Current to Regulate Cerebellar Purkinje Neuron Response to Type-1 Metabotropic Glutamate Receptor Activation

During strong parallel fiber stimulation, glutamate released at parallel fiber-Purkinje cell synapses activates type-1 metabotropic glutamate receptor (mGluR1) to trigger a slow excitatory postsynaptic current (sEPSC) in cerebellar Purkinje neurons. The sEPSC is mediated by transient receptor potent...

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Bibliographic Details
Main Authors: Jinbin Tian, Michael X. Zhu
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:Cells
Subjects:
transient receptor potential
TRPC3
mGluR1
GABAB
EPSC
Purkinje cell
cerebellum
Online Access:http://www.mdpi.com/2073-4409/7/8/90

Internet

http://www.mdpi.com/2073-4409/7/8/90

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