Tracing the evolution of the heterotrimeric G protein α subunit in Metazoa

Tracing the evolution of the heterotrimeric G protein α subunit in Metazoa

Abstract Background Heterotrimeric G proteins are fundamental signaling proteins composed of three subunits, Gα and a Gβγ dimer. The role of Gα as a molecular switch is critical for transmitting and amplifying intracellular signaling cascades initiated by an activated G protein Coupled Receptor (GPC...

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Bibliographic Details
Main Authors: A. D. Lokits, H. Indrischek, J. Meiler, H. E. Hamm, P. F. Stadler
Format: Article
Language:English
Published: BioMed Central 2018-04-01
Series:BMC Evolutionary Biology
Subjects:
Heterotrimeric G protein
G protein coupled receptors
Evolution
Whole genome duplication
Paralog
Orthology
Online Access:http://link.springer.com/article/10.1186/s12862-018-1147-8

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http://link.springer.com/article/10.1186/s12862-018-1147-8

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