Clinicopathologic Significance of VHL Gene Alteration in Clear-Cell Renal Cell Carcinoma: An Updated Meta-Analysis and Review

Clinicopathologic Significance of VHL Gene Alteration in Clear-Cell Renal Cell Carcinoma: An Updated Meta-Analysis and Review

The von Hippel-Lindau (VHL) gene is inactivated frequently in sporadic clear-cell renal cell carcinomas (ccRCCs) by genetic alteration (mutation, loss of heterozygosity, or promoter hypermethylation). However, the pathological or prognostic significance of VHL gene alteration has not been well defin...

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Bibliographic Details
Main Authors: Hyeong Su Kim, Jung Han Kim, Hyun Joo Jang, Boram Han, Dae Young Zang
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:International Journal of Molecular Sciences
Subjects:
renal cell carcinoma
von Hippel-Lindau
mutations
methylation
meta-analysis
review
Online Access:http://www.mdpi.com/1422-0067/19/9/2529

Internet

http://www.mdpi.com/1422-0067/19/9/2529

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