The adhesion and migration of microglia to β-amyloid (Aβ) is decreased with aging and inhibited by Nogo/NgR pathway

The adhesion and migration of microglia to β-amyloid (Aβ) is decreased with aging and inhibited by Nogo/NgR pathway

Abstract Background Alzheimer’s disease is characterized by progressive accumulation of β-amyloid (Aβ)-containing amyloid plaques, and microglia play a critical role in internalization and degradation of Aβ. Our previous research confirmed that Nogo-66 binding to Nogo receptors (NgR) expressed on mi...

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Bibliographic Details
Main Authors: Yinquan Fang, Jianing Wang, Lemeng Yao, Chenhui Li, Jing Wang, Yuan Liu, Xia Tao, Hao Sun, Hong Liao
Format: Article
Language:English
Published: BioMed Central 2018-07-01
Series:Journal of Neuroinflammation
Subjects:
Nogo
Nogo receptor
Microglia
Aβ
Adhesion
Migration
Online Access:http://link.springer.com/article/10.1186/s12974-018-1250-1

Internet

http://link.springer.com/article/10.1186/s12974-018-1250-1

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