A thiol probe for measuring unfolded protein load and proteostasis in cells

A thiol probe for measuring unfolded protein load and proteostasis in cells

Proteostasis is maintained through a number of molecular mechanisms, some of which function to protect the folded state of proteins. Here the authors demonstrate the use of TPE-MI in a fluorigenic dye assay for the quantitation of unfolded proteins that can be used to assess proteostasis on a cellul...

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Bibliographic Details
Main Authors: Moore Z. Chen, Nagaraj S. Moily, Jessica L. Bridgford, Rebecca J. Wood, Mona Radwan, Trevor A. Smith, Zhegang Song, Ben Zhong Tang, Leann Tilley, Xiaohong Xu, Gavin E. Reid, Mahmoud A. Pouladi, Yuning Hong, Danny M. Hatters
Format: Article
Language:English
Published: Nature Publishing Group 2017-09-01
Series:Nature Communications
Online Access:http://link.springer.com/article/10.1038/s41467-017-00203-5

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http://link.springer.com/article/10.1038/s41467-017-00203-5

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